structure of 3TC/d4T

 >
 > TJ O'Donnell asked about d4T (and I have no idea, what it could be).
 > He also mentioned 3TC:
 >
 > Maybe it would be of general interest to know how you found it ?
 > [ I could not, and asked my chemistry friends, who informed me
 >   that it is (2'R-cis)-2'-deoxy-3'-thiacytidine ]
 I found 3TC referred to in
 http://health.nyam.org:8000/public_html/network/sf.html
 after a NetSearch using http://home.mcom.com/home/internet-search.html
 Info in sf.html connected 3TC to Epivir and lamivudine.
 I usually rely on the Merck Index to decipher the plethora
 of chemical synonyms, but the latest edition (1989) did not
 have these relatively new drugs.  Is there a Merck Index on-line?
 I thought I heard about this a while back.  Sure would be swell.
 >
 > While we are at it, TJ O'Donnell wants "a real structure (2D or 3D) of
 d4T".
 > That made me wonder just how commonly used Smiles strings are.
 > Would most CCL'ers be able to decipher
 "N1C(=O)N(C=C[C]1N)C2OC(C3C2S3)CO"
 > as the equivalent of 2'R-cis)-2'-deoxy-3'-thiacytidine (minus chirality) ?
 > Commercial software like Catalyst, Daylight and Sybyl support it,
 > but is there anything for academic users ?
 >
 > Leif Norskov
 > Novo Nordisk A/S
 > Copenhagen
 > Denmark
 > lnl(-(at)-)novo.dk
 I would like to see wider acceptance and use of Smiles strings
 to name chemical structures.  There are extensions of Smiles to
 handle chirality.  I know Concord supports Smiles.  Is that
 "for academic users"?  Does Concord exists outside of Sybyl?
 Steve Layten wrote in response to my inquiry about d4T and 3TC:
 2-D structure diagrams can be obtained for both substances in the CAS Registry
 file on STN. A CONCORD (Tripos, Inc.) generated 3D structure of the latter
 substance can be downloaded from STN.
 Can STN be used to generate 3D structures from 2D smiles that I input?
 TJ
 --
 *---------------------------------------------------------------------*
 *     If you need a quote: http://www.eecs.uic.edu/~tj/quotes.html    *
 *---------------------------------------------------------------------*
 | Dr. TJ O'Donnell  > tj(-(at)-)eecs.uic.edu <  http://www.eecs.uic.edu/~tj/ |
 *---------------------------------------------------------------------*