CCL: failed drugs
- From: "Conley, Michael"
<mconley]_[leadscope.com>
- Subject: CCL: failed drugs
- Date: Mon, 24 Nov 2008 10:22:53 -0500
Sent to CCL by: "Conley, Michael" [mconley#,#leadscope.com]
Leadscope has the FDA Marketed Drugs database that shows discontinued
drugs; however, it doesn't specifically list why the was discontinued.
More information is available on this database at
http://www.leadscope.com/product_info.php?products_id=53
including a short pre-recorded demonstration.
Mike Conley
-----Original Message-----
> From: owner-chemistry+mconley==leadscope.com * ccl.net
[mailto:owner-chemistry+mconley==leadscope.com * ccl.net] On
Behalf Of Joe
Corkery jcorkery|a|eyesopen.com
Sent: Sunday, November 23, 2008 4:01 PM
To: Conley, Michael
Subject: CCL: failed drugs
Sent to CCL by: Joe Corkery [jcorkery() eyesopen.com]
I am not aware of a single database which contains this information, but
most of the prominent medical journals (e.g. NEJM, JAMA, Lancet, Annals
of Internal Medicine, etc) began requiring in 2005 that all clinical
trials be registered at their initiation in order for them to be
considered for publication at a later date. www.clinicaltrials.gov was
referenced back in the original article as being the only registry at
that time (2004) which met their criteria. This site is relatively new
(i.e. will only have data from this decade) but going forward this could
be a valuable resource. From the follow up article in these journals
regarding trial registration (2007) it stated that an additional four
registries were created or became compliant since the original
publication that met their criteria (sadly, they don't list these
registries). One of these might be the WHO registry which can be found
at: http://www.who.int/ictrp/en/.
If you go to either of the sites and simply search for the terms
terminated or withdrawn it gives you a long list of studies which can be
viewed. You can pair these terms with therapeutic areas as well for more
detailed searches.
With regards to approved drugs, the FDA reported a list of drugs
withdrawn up to 2005 in the following document:
http://www.fda.gov/CDER/reports/rtn/2005/rtn2005-4.htm
And active post-market studies can be found here:
http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfPMA/pma_pas.cfm
Hopefully, you will be able to find some or all of these sites useful.
Best of luck,
Joe Corkery
OpenEye Scientific Software
-----Original Message-----
> From: owner-chemistry+jcorkery==eyesopen.com~!~ccl.net
[mailto:owner-chemistry+jcorkery==eyesopen.com~!~ccl.net] On Behalf Of
James T Metz James.Metz]_[Abbott.com
Sent: Friday, November 21, 2008 5:00 PM
To: Joe Corkery
Subject: CCL: failed drugs
Sent to CCL by: "James T Metz" [James.Metz .. Abbott.com]
CCL,
Does anyone maintain a well-curated list of failed drugs or failed drug
candidates and when they failed e.g., Phase II, Phase III, market, etc.
Such a list might be useful for making comparisons to drugs which did
not
fail.
Useful literature references or other sources of information would be
much appreciated.
Regards,
Jim Metz
Abbott Laboratories
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