CCL: failed drugs

 Sent to CCL by: Joe Corkery [jcorkery()]
 I am not aware of a single database which contains this information, but most of
 the prominent medical journals (e.g. NEJM, JAMA, Lancet, Annals of Internal
 Medicine, etc) began requiring in 2005 that all clinical trials be registered at
 their initiation in order for them to be considered for publication at a later
 date. was referenced back in the original article as
 being the only registry at that time (2004) which met their criteria. This site
 is relatively new (i.e. will only have data from this decade) but going forward
 this could be a valuable resource. From the follow up article in these journals
 regarding trial registration (2007) it stated that an additional four registries
 were created or became compliant since the original publication that met their
 criteria (sadly, they don't list these registries). One of these might be the
 WHO registry which can be found at:
 If you go to either of the sites and simply search for the terms terminated or
 withdrawn it gives you a long list of studies which can be viewed. You can pair
 these terms with therapeutic areas as well for more detailed searches.
 With regards to approved drugs, the FDA reported a list of drugs withdrawn up to
 2005 in the following document:
 And active post-market studies can be found here:
 Hopefully, you will be able to find some or all of these sites useful. Best of
 Joe Corkery
 OpenEye Scientific Software
 -----Original Message-----
 > From:[a] [[a]] On Behalf Of James
 T Metz James.Metz]_[
 Sent: Friday, November 21, 2008 5:00 PM
 To: Joe Corkery
 Subject: CCL: failed drugs
 Sent to CCL by: "James T Metz" [James.Metz ..]
 Does anyone maintain a well-curated list of failed drugs or failed drug
 candidates and when they failed e.g., Phase II, Phase III, market, etc.
 Such a list might be useful for making comparisons to drugs which did not
 Useful literature references or other sources of information would be much
 Jim Metz
 Abbott Laboratories
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