From owner-chemistry@ccl.net Sun Nov 23 20:43:00 2008 From: "Joe Corkery jcorkery|a|eyesopen.com" To: CCL Subject: CCL: failed drugs Message-Id: <-38151-081123163106-3658-nBkAMdlhYIDR4+1e5eSIDQ**server.ccl.net> X-Original-From: Joe Corkery Content-Language: en-US Content-Transfer-Encoding: quoted-printable Content-Type: text/plain; charset="us-ascii" Date: Sun, 23 Nov 2008 13:00:40 -0800 MIME-Version: 1.0 Sent to CCL by: Joe Corkery [jcorkery() eyesopen.com] I am not aware of a single database which contains this information, but mo= st of the prominent medical journals (e.g. NEJM, JAMA, Lancet, Annals of In= ternal Medicine, etc) began requiring in 2005 that all clinical trials be r= egistered at their initiation in order for them to be considered for public= ation at a later date. www.clinicaltrials.gov was referenced back in the or= iginal article as being the only registry at that time (2004) which met the= ir criteria. This site is relatively new (i.e. will only have data from thi= s decade) but going forward this could be a valuable resource. From the fol= low up article in these journals regarding trial registration (2007) it sta= ted that an additional four registries were created or became compliant sin= ce the original publication that met their criteria (sadly, they don't list= these registries). One of these might be the WHO registry which can be fou= nd at: http://www.who.int/ictrp/en/. If you go to either of the sites and simply search for the terms terminated= or withdrawn it gives you a long list of studies which can be viewed. You = can pair these terms with therapeutic areas as well for more detailed searc= hes. With regards to approved drugs, the FDA reported a list of drugs withdrawn = up to 2005 in the following document: http://www.fda.gov/CDER/reports/rtn/2005/rtn2005-4.htm And active post-market studies can be found here: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfPMA/pma_pas.cfm Hopefully, you will be able to find some or all of these sites useful. Best= of luck, Joe Corkery OpenEye Scientific Software -----Original Message----- > From: owner-chemistry+jcorkery=3D=3Deyesopen.com[a]ccl.net [mailto:owner-chem= istry+jcorkery=3D=3Deyesopen.com[a]ccl.net] On Behalf Of James T Metz James.M= etz]_[Abbott.com Sent: Friday, November 21, 2008 5:00 PM To: Joe Corkery Subject: CCL: failed drugs Sent to CCL by: "James T Metz" [James.Metz .. Abbott.com] CCL, Does anyone maintain a well-curated list of failed drugs or failed drug can= didates and when they failed e.g., Phase II, Phase III, market, etc. Such a list might be useful for making comparisons to drugs which did not fail. Useful literature references or other sources of information would be much = appreciated. Regards, Jim Metz Abbott Laboratories -=3D This is automatically added to each message by the mailing script =3D-http://www.ccl.net/cgi-bin/ccl/send_ccl_messagehttp://www.ccl.net/chemistry/sub_unsub.shtmlhttp://www.ccl.net/spammers.txt