CCL: Dihydroxyl compound
- From: "Dominic Ryan"
<dominic.ryan*|*comcast.net>
- Subject: CCL: Dihydroxyl compound
- Date: Wed, 10 May 2006 11:06:45 -0400
Kevin,
There is an equilibrium between dihydroxyl and carbonyl + water. Unless
there is a strong electron withdrawing group, or significant steric strain
due to a small ring, or an enzyme transition state to stabilize it, such a
dihydroxyl compound will not be stable and the equilibrium lies far on the
carbonyl side. Basic organic texts should cover this.
Dominic
Ps, direct mail to your address bounced.
-----Original Message-----
> From: owner-chemistry..ccl.net [mailto:owner-chemistry..ccl.net]
Sent: Wednesday, May 10, 2006 8:52 AM
To: Ryan, M Dominic
Subject: CCL: Dihydroxyl compound
Sent to CCL by: kevin abbot [kevanabbot::yahoo.com]
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Hi CCLers,
I am working on a compound which has two hydroxyl groups on the same
secondary carbon atom (not primary),
might someone inform me about the stability of a dihydroxyl compound and
its synthetic reliability (I mean is a compound like this stable?).
Some references are appreciated as I have found only a few articles on
this kind of compound.
Best Regards
Kevin
---------------------------------
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lang=EN-GB
style="mso-ansi-language: EN-GB"><FONT size=3><FONT
face="Times New
Roman">Hi CCLers,<?xml:namespace prefix = o ns =
"urn:schemas-microsoft-com:office:office"
/><o:p></o:p></FONT></FONT></SPAN></div>
<div class=MsoNormal
style="MARGIN: 0cm 0cm 0pt"><SPAN lang=EN-GB
style="mso-ansi-language:
EN-GB"><FONT size=3><FONT face="Times New
Roman">I am
working on a compound which has two hydroxyl groups on the
same
secondary carbon atom (not
primary),<o:p></o:p></FONT></FONT></SPAN></div>
<div class=MsoNormal style="MARGIN: 0cm 0cm 0pt"><SPAN
lang=EN-GB
style="mso-ansi-language: EN-GB"><FONT size=3><FONT
face="Times New
Roman">might someone inform me about the stability of a dihydroxyl
compound
and its synthetic reliability (I mean is a compound like this
stable?).<o:p></o:p></FONT></FONT></SPAN></div>
<div class=MsoNormal
style="MARGIN: 0cm 0cm 0pt"><SPAN lang=EN-GB
style="mso-ansi-language:
EN-GB"><FONT size=3><FONT face="Times New
Roman">Some references are
appreciated as I have found only a few articles on this kind of
compound.<o:p></o:p></FONT></FONT></SPAN></div>
<div class=MsoNormal
style="MARGIN: 0cm 0cm 0pt"><SPAN lang=EN-GB
style="mso-ansi-language:
EN-GB"><o:p><FONT face="Times New Roman"
size=3> </FONT></o:p></SPAN></div> <div
class=MsoNormal style="MARGIN:
0cm 0cm 0pt"><SPAN lang=EN-GB style="mso-ansi-language:
EN-GB"><FONT
size=3><FONT face="Times New Roman">Best
Regards<o:p></o:p></FONT></FONT></SPAN></div>
<div class=MsoNormal
style="MARGIN: 0cm 0cm 0pt"><SPAN lang=EN-GB
style="mso-ansi-language:
EN-GB"><o:p><FONT face="Times New Roman"
size=3> </FONT></o:p></SPAN></div> <div
class=MsoNormal style="MARGIN:
0cm 0cm 0pt"><SPAN lang=EN-GB style="mso-ansi-language:
EN-GB"><FONT
size=3><FONT face="Times New
Roman">Kevin<o:p></o:p></FONT></FONT></SPAN></div>
<div> </div><p>
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<p class=3DMsoNormal><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:10.0pt;
font-family:"Courier New"'>Kevin,
<o:p></o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:10.0pt;
font-family:"Courier
New"'><o:p> </o:p></span></font></p>
<p class=3DMsoNormal><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:10.0pt;
font-family:"Courier New"'>There is an equilibrium between
dihydroxyl =
and
carbonyl + water. Unless there is a strong electron withdrawing =
group, or
significant steric strain due to a small ring, or an enzyme transition =
state to
stabilize it, such a dihydroxyl compound will not be stable and the =
equilibrium
lies far on the carbonyl side. Basic organic texts should =
cover this. <o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'><o:p> </o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>Dominic<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'><o:p> </o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>Ps, direct mail to your address =
bounced.<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'><o:p> </o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>-----Original Message-----<br>
> From: owner-chemistry..ccl.net [mailto:owner-chemistry..ccl.net] <br>
Sent: Wednesday, May 10, 2006 8:52 AM<br>
To: Ryan, M Dominic <br>
Subject: CCL: Dihydroxyl compound</span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'><o:p> </o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>Sent to CCL by: kevin abbot =
[kevanabbot::yahoo.com]<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>--0-512180785-1147267732=3D:41797<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
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charset=3Diso-8859-1<o:p></o:p></span></font></p>
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<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>Hi CCLers,<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'> I am working on a compound which has two hydroxyl groups =
on the same
secondary carbon atom (not
primary),<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'> might someone inform me about the stability of a =
dihydroxyl compound
and its synthetic reliability (I mean is a compound like this =
stable?).<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'> Some references are appreciated as I have found only a =
few articles
on this kind of
compound.<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>
<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'> Best
Regards<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>
<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>
Kevin<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>
<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'><o:p> </o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>  =
; <o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>---------------------------------<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>New Yahoo! Messenger with Voice. Call regular phones from your =
PC and
save big.<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'>--0-512180785-1147267732=3D:41797<o:p></o:p></span></font></p>
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10.0pt'><o:p> </o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'><div class=3DMsoNormal style=3D"MARGIN: 0cm 0cm
0pt"><SPAN lang=3DEN-GB
style=3D"mso-ansi-language:
EN-GB"><FONT size=3D3><FONT
face=3D"Times New
Roman">Hi CCLers,<?xml:namespace prefix =3D o ns =3D =
"urn:schemas-microsoft-com:office:office"
/><o:p></o:p></FONT></FONT></SPAN></d=
iv>
<div class=3DMsoNormal style=3D"MARGIN: 0cm 0cm =
0pt"><SPAN
lang=3DEN-GB style=3D"mso-ansi-language:
EN-GB"><FONT
size=3D3><FONT face=3D"Times New
Roman">I&nbsp;am
working&nbsp;on&nbsp;a compound which has two hydroxyl groups on
=
the
same secondary carbon atom (not
primary),<o:p></o:p></FONT></FONT></SPAN>&l=
t;/div>
<div class=3DMsoNormal style=3D"MARGIN: 0cm 0cm =
0pt"><SPAN
lang=3DEN-GB style=3D"mso-ansi-language:
EN-GB"><FONT
size=3D3><FONT face=3D"Times New
Roman">might someone =
inform me
about the stability of a dihydroxyl compound and its synthetic =
reliability (I
mean is a compound like this
stable?).<o:p></o:p></FONT></FONT></SPAN>&l=
t;/div>
<div class=3DMsoNormal style=3D"MARGIN: 0cm 0cm =
0pt"><SPAN
lang=3DEN-GB =
style=3D"mso-ansi-language:<o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
New"><span =
style=3D'font-size:
10.0pt'> EN-GB"><FONT
size=3D3><FONT =
face=3D"Times New Roman">Some
references are appreciated as I have found only a few articles on this =
kind of
compound.<o:p></o:p></FONT></FONT></SPAN>&l=
t;/div>
<div class=3DMsoNormal style=3D"MARGIN: 0cm 0cm =
0pt"><SPAN
lang=3DEN-GB style=3D"mso-ansi-language: =
EN-GB"><o:p><FONT
face=3D"Times New Roman"
size=3D3>&nbsp;</FONT></o:p></SPAN></div>&=
nbsp; <div
class=3DMsoNormal style=3D"MARGIN: 0cm 0cm
0pt"><SPAN =
lang=3DEN-GB
style=3D"mso-ansi-language: EN-GB"><FONT =
size=3D3><FONT face=3D"Times
New Roman">Best
Regards<o:p></o:p></FONT></FONT></SPAN><=
/div>
<div class=3DMsoNormal style=3D"MARGIN: 0cm 0cm =
0pt"><SPAN
lang=3DEN-GB style=3D"mso-ansi-language: =
EN-GB"><o:p><FONT
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0pt"><SPAN =
lang=3DEN-GB
style=3D"mso-ansi-language: EN-GB"><FONT =
size=3D3><FONT
face=3D"Times New
Roman">Kevin<o:p></o:p></FONT></FONT><=
/SPAN></div>
<div>&nbsp;</div><p><o:p></o:p></span></font></p>
<p class=3DMsoPlainText><font size=3D2 face=3D"Courier
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