QSAR equation

Hi,
     I was wondering about one thing which could be a simple query for
 many of you.
 What is the significance of cross correlation of independent terms in a
 QSAR equation generated using multiple regression?
 If I have a QSAR equation with high cross correlation of independent
 terms but the prediction of test compounds are good, should I consider
 this equation seriously?
 Any suggestion or literature reference on this would be highly
 appreciated.
 Thanks.
 Sudhir
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