Conformational analysis of nucleosides



Hi All!
 My question to you fellow CClers is as follows:
 I need to analyze (computationally) the conformations of various
 nucleosides, and ribonucleosides having modifications in the furanose and
 the heterocyclic base regions. Are you aware of any commercial and/ or
 shareware package that can achieve this. I will need to calculate atomic
 charges, assign proper atom properties and then perform molecular mechanics
 and dynamics simulations to assign determine the likely conformation of the
 molecules under study. A program that has the requisite force fields ( any
 suggestions for the proper force field to use would be appreciated), and
 should have reasonable cost and hardware requirements ( PC compatibility
 would be best).
 I look forward to the usual helpful responses and thank all respondents in
 advance.
 Sincerely,
 Prasad Dande
 **************************************************************************************************************************************************************
 Prasad Dande, Ph. D.
 Senior Scientist
 Research Chemistry
 ISIS Pharmaceuticals
 2292 Faraday Avenue
 Carlsbad, CA 92008
 Tel: 760 603 4671
 Fax: 760 603 4654
 Prasad_Dande (- at -) isisph.com