From owner-chemistry %-% at %-% ccl.net Mon Nov 24 11:54:01 2008 From: "Conley, Michael mconley~~leadscope.com" To: CCL Subject: CCL: failed drugs Message-Id: <-38163-081124111032-28322-h6GbZ8AjmzIw6ZYiPq2vSQ---server.ccl.net> X-Original-From: "Conley, Michael" Content-class: urn:content-classes:message Content-Transfer-Encoding: quoted-printable Content-Type: text/plain; charset="us-ascii" Date: Mon, 24 Nov 2008 10:22:53 -0500 MIME-Version: 1.0 Sent to CCL by: "Conley, Michael" [mconley#,#leadscope.com] Leadscope has the FDA Marketed Drugs database that shows discontinued drugs; however, it doesn't specifically list why the was discontinued. More information is available on this database at http://www.leadscope.com/product_info.php?products_id=3D53=20 including a short pre-recorded demonstration. Mike Conley -----Original Message----- > From: owner-chemistry+mconley=3D=3Dleadscope.com * ccl.net [mailto:owner-chemistry+mconley=3D=3Dleadscope.com * ccl.net] On Behalf Of = Joe Corkery jcorkery|a|eyesopen.com Sent: Sunday, November 23, 2008 4:01 PM To: Conley, Michael Subject: CCL: failed drugs Sent to CCL by: Joe Corkery [jcorkery() eyesopen.com] I am not aware of a single database which contains this information, but most of the prominent medical journals (e.g. NEJM, JAMA, Lancet, Annals of Internal Medicine, etc) began requiring in 2005 that all clinical trials be registered at their initiation in order for them to be considered for publication at a later date. www.clinicaltrials.gov was referenced back in the original article as being the only registry at that time (2004) which met their criteria. This site is relatively new (i.e. will only have data from this decade) but going forward this could be a valuable resource. From the follow up article in these journals regarding trial registration (2007) it stated that an additional four registries were created or became compliant since the original publication that met their criteria (sadly, they don't list these registries). One of these might be the WHO registry which can be found at: http://www.who.int/ictrp/en/. If you go to either of the sites and simply search for the terms terminated or withdrawn it gives you a long list of studies which can be viewed. You can pair these terms with therapeutic areas as well for more detailed searches. With regards to approved drugs, the FDA reported a list of drugs withdrawn up to 2005 in the following document: http://www.fda.gov/CDER/reports/rtn/2005/rtn2005-4.htm And active post-market studies can be found here: http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfPMA/pma_pas.cfm Hopefully, you will be able to find some or all of these sites useful. Best of luck, Joe Corkery OpenEye Scientific Software -----Original Message----- > From: owner-chemistry+jcorkery=3D=3Deyesopen.com~!~ccl.net [mailto:owner-chemistry+jcorkery=3D=3Deyesopen.com~!~ccl.net] On Behalf = Of James T Metz James.Metz]_[Abbott.com Sent: Friday, November 21, 2008 5:00 PM To: Joe Corkery Subject: CCL: failed drugs Sent to CCL by: "James T Metz" [James.Metz .. Abbott.com] CCL, Does anyone maintain a well-curated list of failed drugs or failed drug candidates and when they failed e.g., Phase II, Phase III, market, etc. Such a list might be useful for making comparisons to drugs which did not fail. Useful literature references or other sources of information would be much appreciated. Regards, Jim Metz Abbott Laboratories -=3D This is automatically added to each message by the mailing script =3D-http://www.ccl.net/cgi-bin/ccl/send_ccl_messagehttp://www.ccl.net/che= m istry/sub_unsub.shtmlhttp://www.ccl.net/spammers.txt -=3Dhis is automatically added to each message by the mailing script =3Dhttp://www.ccl.net/cgi-bin/ccl/send_ccl_messageSubscribe/Unsubscribe:=20Job: http://www.ccl.net/jobs=20http://www.ccl.net/spammers.txt