COMPUTERS & CHEMISTRY An International Journal _____________________________________________________ Contents Vol.18, No. 3, 1994 _____________________________________________________ OPEN PROBLEMS OF COMPUTATIONAL MOLECULAR BIOLOGY (3) v Andrzej K Konopka Editorial Area 1: Computational Issues in Genone Research 203 James W. Fickett Inferring genes from open reading frames 207 David Greenberg and Sorin Istrail The chimeric mapping problem: algorithmic strategies and performance evaluation on synthetic genomic data Brief Communication 221 Pavel A Pevzner Rearrangements of DNA sequences and SBH Area 2: Protein Structure Prediction 225 Patrick Argos, Ruben Abagyan The protein folding problem: finding a few minimums in a near infinite space 233 Jaap Heringa The evolution and recognition of protein sequence repeats 245 Kerr Hatrick, William R Taylor Sequence conservation and correlation measures in protein structure prediction Application Note 251 Volker Brendel, Samuel Karlin Applications of statistical criteria in protein sequence analysis: case study of yeast RNA polymerase II Area 3: Mathematical Techniques in Sequence Research 255 Chip Lawrence Toward the unification of sequence and structural data for identification of structural and functional constraints 259 Mark Borodovsky, Anatoly Peresetsky Deriving non-homogenous DNA Markov chain models by cluster analysis algorithm minimizing multiple alignment entropy 269 John C Wootton Non-globular domains in protein sequences: automated segmentation using complexity measures Brief Communication 287 Jean-Michel Claverie Some useful statistical properties of position-weight matrices Area 4: Modeling Evolution and Development 295 Peter Schuster, Peter F Stadler Landscapes: complex optimization problems and biopolymer structures 325 Richard Gordon Evolution escapes rugged fitness landscapes by gene or 333 Natalie K Bjorklund, Richard Gordon Surface contraction and expansion waves correlated with differentiation in axolotl embryos-1. Prolegomenon and diffferentiation during invagination through the blastopore, as shown by the fate map Area 5: Overviews and Opinions 347 Robert Rosen What is biology? 353 R W Hamming Science is in the eye of the beholder ================================================================= COMPUTERS & CHEMISTRY An International Journal ______________________________________________________________________________ Contents Vol. 18, No.4 1994 ______________________________________________________________________________ 359 F T Chau, B Cheung,, K Y Tam and L K Li Application of a bi-directional associative memory (BAM) network in computer assisted learning in chemistry 363 Zhong-Heng Yu Quantitative perturbational molecular orbital analysis of the conformational preference of the aniline molecule and its intramolecular force (II) 371 Karl Nedwed, Karl Gatterer, and Harald Paulson Fritzer SYMAPPS 1.0: a software packet for group theoretical applications to molecular symmetry 377 L Fernandez Pacios ARVOMOL/CONTOUR: molecular surface areas and volumes on Personal Computers 387 Roman Wojsz, Ryszard Mikulski A microcomputer program for the determination of the structural parameters of microporous solids 391 Xin-Hua Song, Min Xiao, and Ru-Qin Yu Artificial neural networks applied to classification of mutagenic activity of nitro-substituted polycyclic aromatic hydrocarbons 397 Soren Balling Engelsen, Jesper Fabricius, Kjeld Rasmussen Interactive graphical optimization of potential energy function parameters in the consistent force field 405 Enrico Cavalli, Roberto Cammi SYMMETRY: a computer program for the analysis of the distortions of the MX6(0h) and MX4(Td) complexes in crystalline environments 413 C Munoz-Caro and A Nino Vibrational energy levels and vibronic structure of electronic spectra in molecules with large amplitude motions 419 S Bhattacharjee Haloethanes, geometric volume and atomic contribution method Meeting Report 431 Ante Graovac The Eighth Dubrovnik MATH/CHEM/COMP International Course and Conference and the First Croation Meeting on Fullerness Software Note 433 Oeyvind Edvardsen CLIFF: a command-line file specification front-end to unix programs. Application to AMBER 4 Book Reviews 435 Nenad Trinajstic Chemical nomenclatures and the computer by D J Polton 437 Barry K Lavine Chemometrics for analytical chemistry, Vol 1: PC- aidedstatistical data analysis by M Meloun, J Militky and M Forina 437 John D Catrel Practical computer vision in C by J R Parker