From: jobs at ccl.net (do not send your application there!!!)<br />
To: jobs at ccl.net<br />
Date: Fri May 10 09:32:06 2024<br />
Subject: <STRONG>24.05.10 PhD position in structure-based RNA-ligand design</STRONG><br />

<pre>
At the University of Bergen (Norway), Faculty of Medicine, Department of Biomedicine in the group of Professor Ruth Brenk (<a href="http://www.uib.no/en/rg/brenk" target="_blank">http://www.uib.no/en/rg/brenk</a>), 
a PhD-position (100 %) is available for a period of four years. 
The candidates must be able to start the position latest mid-August 2024.


The main objectives for the advertised PhD position are:

- to carry out structure-based design of RNA-ligands
- to establish computational methodology on how to harvest the potential of large, chemically accessible combinatorial spaces 
  for the design of RNA ligands
- to determine the binding affinities of RNA ligands
- to determine the crystal structures of RNA-ligand complexes

More Information about the project can be found here: <a href="https://www.uib.no/en/rg/brenk/162656/paving-way-rational-rna-ligand-design" target="_blank">https://www.uib.no/en/rg/brenk/162656/paving-way-rational-rna-ligand-design</a>.

This is a great opportunity to combine working on a challenging project with enjoying the outstanding nature that Norway has to offer.

Qualifications and personal qualities:

- The applicant must hold a master`s degree or equivalent within the field of 
  cheminformatics, bioinformatics, pharmacy, medicinal chemistry, or a related discipline, 
  or must have submitted his/her master's thesis for assessment prior to 30th of June 2024. 
  It is a condition of employment that the master's degree has been awarded before the start of the position mid-August 2024.
- The applicant must have a thorough understanding of structure-based ligand design.
- Basic knowledge of a scripting language is required.
- Experience with RDKit is a distinct advantage.
- Experience with modelling RNA structures or RNA-ligand interactions is a distinct advantage.
- Training in organic synthesis or medicinal chemistry is a distinct advantage.
- Experience with using biophysical methods for determination of binding affinities is a distinct advantage
- Experience in X-ray crystallography is a distinct advantage.
- The candidate must demonstrate a strong commitment and enthusiasm for structure-based drug design of RNA-ligands 
  and for research in general. 
- The candidate must be able to work independently and interactively in a team setting. 
- A structured approach to work and excellent communication skills and fluency in both written and spoken English are required.</pre>
<pre>
More details and instructions on how to apply can be found here: <a href="https://www.jobbnorge.no/en/available-jobs/job/262809/phd-position-in-structure-based-rna-ligand-design" target="_blank">https://www.jobbnorge.no/en/available-jobs/job/262809/phd-position-in-structure-based-rna-ligand-design</a></pre>
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