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Up Directory CCL 22.06.07 Associate Director / Director, Computational Chemistry (Cheminformatics, Small Molecules), METiS Therapeutics, Cambridge (Boston), MA, USA
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Date: Tue Jun 7 15:35:31 2022
Subject: 22.06.07 Associate Director / Director, Computational Chemistry (Cheminformatics, Small Molecules), METiS Therapeutics, Cambridge (Boston), MA, USA
Title: Associate Director / Director , Computational Chemistry (Cheminformatics, Small Molecules) 
Reports To: President and Head of R&D
Company: METiS Therapeutics 
Location: Cambridge, MA USA
Website: www.metistx.com
To apply: recruiting]*[metistx.com


METiS Therapeutics Inc is a biotechnology company with a unique technology platform that has the potential to drive best-in class drug assets in a wide range of therapeutic areas. Through the integration of machine learning, quantum simulation, and high-throughput experimentation, we enable scientists to rapidly, comprehensively, and intelligently develop novel drug candidates. METiS is founded by an enthusiastic team of MIT researchers and serial entrepreneurs. Our cross-disciplinary expertise and deep industry experiences allow METiS to harness AI to boldly deliver revolutionary therapies for patients with serious diseases.
We are looking for an experienced computational chemist with robust knowledge and proven skill sets in molecular modeling. A key element of her/him is a strong interest in data- and hypothesis- driven drug discovery by applying state-of-the-art computational chemistry methods, including structure- and ligand-based design, virtual screening, free energy simulation, and molecular dynamics. As a key member of the team, she/he is expected to work independently and demonstrate scientific leadership and creativity within a multi-disciplinary environment.

Responsibilities 
	Work with a high degree of independence to carry out structure and ligand-based design and data analysis
	Support all aspects of the companys computational chemistry efforts targeting multiple cellular pathways/mechanism and indications
	Develop and implement computational chemistry approaches to design and triage compound ideas
	Closely collaborate and communicate with medicinal chemists and biologists to understand current issues and provide effective solutions
	Proactively propose strategies for effective use of computational chemistry to accelerate hit-to-lead and lead optimization toward clinical candidates
	Create machine learning/AI strategies through communication with global colleagues and exploit the methodologies to implement a more effective design environment 
	Participate in interdisciplinary teams and external collaborations
	Work in a fast-paced/small-team environment that is growing and evolving and which requires regular reprioritization of projects while adhering to timelines and achievement of deliverables

Minimum Qualifications
	Ph.D. in computational chemistry or related discipline with 8+ years in the biotech/pharmaceutical industry. 
	A proven record of scientific leadership and innovation as demonstrated by publications, presentations, and / or patents 
	Practical experience in structure-based drug design, including docking, homology modeling, molecular dynamics simulation, and free energy calculation; ligand-based drug design, including pharmacophore modeling, QSAR, pharmacophore- or shape-based database searching, combinatorial library design, and target focused library construction
	Robust understanding of Linux command line is required in addition to strong programming/scripting capabilities (Python, R, Schrodinger/OEChem and machine learning APIs, including Scikit-learn and Tensorflow) 
	Practical experience with cloud computing environments such as AWS, Microsoft Azure, or GCloud 
	Familiarity with Collaborative Drug Discovery or Dotmatics software a plus
	Ability to multitask and support multiple projects simultaneously
	Experience managing external collaborations, including CROs
	Excellent communication and organizational skills are required
	Must be willing to relocate full time to Greater Boston Area within 6 months of start date

For information on METiS Tx please visit: www.metistx.com

To apply, please send your resume recruiting]*[metistx.com OR visit our website and submit your application at https://www.metistx.com/join-us

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