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Date: Wed May 4 00:34:24 2022
Subject: 22.05.04 Computational Chemistry Lead/Associate Director, USA

Computational Chemistry Lead/Associate Director, USA

About us
Longwood Fund-backed NewCo is an exciting early-stage biotechnology company developing novel bifunctional small molecules for fine-tuned control of post-translational modifications beyond ubiquitination, building off the same principles that underpin PROTACs. We will unlock directed protein post-translational modifications as a therapeutic strategy to treat a broad range of diseases such as oncology, immunological diseases, and metabolic diseases as well as genetic disorders.

What you will do...

  • In close collaboration with medicinal chemists and project teams, apply a wide variety of drug-design and computational chemistry methods towards hit-finding, optimization of potency, selectivity, and ADME properties while minimizing toxicological risks.
  • Assimilate, summarize, and apply SAR understanding by leveraging physics-based and data-driven modeling technologies to address discovery challenges.
  • Contribute to the enhancement of the computational chemistry and cheminformatics infrastructure by developing, implementing, and deploying state-of-the-art computational tools and workflows.
  • Contribute to the design and implementation of new technologies and approaches to drugging traditionally intractable targets.

About you...

  • PhD, or equivalent, in the field of chemistry or computational chemistry with 8+ years of experience working in small-molecule drug discovery teams in a pharma or biotech setting.
  • Experience leading technical teams and programs.
  • Strong track record of successfully applying computational approaches, including but not limited to SBDD/FBDD, pharmacophore development, data analytics, virtual screening, machine-learning, and molecular dynamics studies to impacting drug discovery.
  • Strong understanding of modern drug discovery including Biology, Medicinal Chemistry, and DMPK principles.
  • Ability to independently solve problems, to think critically and creatively as part of a fast-paced and multidisciplinary team. Ability to help lead, recruit and cultivate a high performing team.
  • Experience with Schrodinger, MOE, Dotmatics, and either KNIME or Pipeline Pilot; Proficiency in Python and the Linux environment a plus.
  • Excellent organizational skills and ability to multi-task in an extremely fast-paced environment.
  • Ability to communicate clearly and concisely with all stakeholders.
  • Strong sense of urgency to help bring new and more effective medicine to patients.
  • Passion for drug discovery and to help accelerate the drug discovery and development process.
  • Goal-driven, operates with a sense of urgency, highly collaborative, open-minded, data-driven, and creative.
  • Ability to dive deep into the details while focused on the big picture.

How to apply:
If interested, please send your resume to Emma Seabrook emma^

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Please let your prospective employer know that you learned about the job from the Computational Chemistry List Job Listing at
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