|CCL 22.03.30 Postdoctoral Fellow, Computational Chemistry, Janssen R&D, La Jolla, CA|
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Date: Wed Mar 30 23:25:10 2022
Subject: 22.03.30 Postdoctoral Fellow, Computational Chemistry, Janssen R&D, La Jolla, CA
Postdoctoral Fellow, Computational Chemistry, Janssen R&D, La Jolla, CA
Location: La Jolla, California
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us at JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.
In Silico approaches play an important role in all stages of drug discovery, including identifying suitable pockets in target proteins capable of binding small molecules. While there are established computational approaches to predict and evaluate ligandable binding sites when reliable protein structures are known, there are often and increasingly so, cases where the putative binding site is potentially flexible and not detectable with current standard approaches known as cryptic pockets.
The Postdoctoral Fellow will primarily aim to develop advanced methodologies and innovative computational approaches combining physics-based, statistical and AI/ML approaches to (a) identify ligandable cryptic pockets and (b) predict allosteric sites. They will utilize the identified sites for ongoing drug discovery projects, for instance applying ultra-high throughput virtual screening or comparisons with other binding sites across the proteome for hit identification. furthermore, they will be responsible for publishing their results, targeting high-impact journals.
Job Responsibilities include, but are not limited to:
Experience with several of the following is required
If interested, please apply on-line at: https://jobs.jnj.com/jobs/2105987963W?lang=en-us&previousLocale=en-US
At Johnson & Johnson, were on a mission to change the trajectory of health for humanity. That starts by creating the worlds healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional, and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work.
For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com .
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.
Primary Location United States-California-La Jolla
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