|CCL 22.03.30 RNA Bioinformatics & Computational Chemist, PharmCADD|
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To: jobs at ccl.net
Date: Wed Mar 30 10:46:00 2022
Subject: 22.03.30 RNA Bioinformatics & Computational Chemist, PharmCADD
Job Summary PharmCADD is seeking highly motivated computational RNA scientists with strong expertise in broad areas of RNA modeling including prediction of secondary and tertiary structures, sequence optimization, designing RNAs as therapeutic agents themselves, target identification, designing small-molecule candidates targeting RNAs and free energy calculations using classical and quantum mechanical approaches. The successful candidates will participate in multiple projects focused on PharmCADDs RNA therapeutics platform, PharmVACTM. Job Descriptions Position 1: RNA Bioinformatics Scientist Essentials: - Hands-on experiences with strong publication record in using RNA secondary and tertiary structure prediction methods (for example, Rosetta, MC-fold, ViennaRNA, etc.) - Ability to apply current RNA modeling approaches and AI-based methods to predict large RNA structures - Experience with RNA sequence optimization approaches for vaccine platforms Position 2: RNA Computational Chemist (Free energy calculations) Essentials: In this role, the candidate will work on studying the thermodynamics of RNAs and their complexes with ligand and proteins - Extensive experience with RNA modeling, molecular dynamics (MD) simulations and RNA force field development and validation approaches - Quantum mechanical calculations of RNAs and its complexes - Proven knowledge of free energy calculations and enhanced sampling methods such as umbrella sampling, metadynamics, accelerated MD, steered MD, scaled-MD, etc. - Candidate is required to have experience with working on massively parallel supercomputing architecture - Intermediate level of coding skills in Python, R and shell scripting - Familiar with different computational chemistry packages and platforms Position 3: RNA Computational Chemist (RNA design and small molecule identification) Essentials: In this role, the candidate will work on designing synthetic RNAs that can be used as a therapeutic, RNA target identification and identifying small-molecule hits targeting RNAs - Solid understanding of RNA structural elements and RNA medicinal chemistry - Experience with molecular dynamics (MD) simulations, free energy calculations and high-throughput quantum mechanical calculations of RNA-ligand complexes - Structure-based and ligand-based approaches of drug designing - Experience with molecular docking and pharmacophore-based approaches for hit identification - Experience with virtual library design - Sound computational chemistry knowledge for lead optimization - Candidate is required to have experience with working on massively parallel supercomputing architecture - Intermediate level of coding skills in Python, R and shell scripting - Familiar with different computational chemistry packages and platforms General Qualifications for Position 1,2,3 : 1. Ph.D.s degree with 0-4 years of experience in a related field (Computational Chemistry, Computational Biophysics, Computational Medicinal Chemistry, Bioinformatics, etc.) 2. Strong publication record in the field of RNA computational chemistry 3. Ability to communicate technical information and scientific concepts in a clear manner 4. Prepare timely reports, presentations Position 4: Data Scientist RNA team Essentials: In this role, the candidate will work closely with Domain experts to generate various Deep learning/machine learning models to support on-going research and to establish deep learning models for RNA Structure prediction and also RNA-small molecule interactions. - Strong coding skills in Python producing maintainable code with good engineering practices, e.g. unit testing, environment and package management - Experience in Machine Learning toolkits (TensorFlow, PyTorch) - Sound knowledge in NLP is a must - Experience and good working knowledge of cloud platform data science offerings from AWS and/or GCP - Excellent communication, team work and a results-oriented attitude - Relevant professional experience with a proven track record in AI/ML model development and deployment - Familiarity with use of database systems and their querying (e.g. SQL, NoSQL, graph) in bioinformatics/data science applications - Demonstrated experience in the use of many bioinformatics tools relating to genomic (DNA/RNA) sequence analysis (will be an added value) - Advanced skills in R, Python and Shell - Basic knowledge of quantum computing will be a plus. - Knowledge of CUDA programming is a plus. Salary and benefit - PharmCADD offers an industry leading competitive compensation package. - Salary will be commensurate with track record and job experience level. - Benefit package includes paid holidays, health insurance, stock option, company supported retirement plan, and housing support.
Application Procedure - Send your application to hr%x%pharmcadd.com with a cover letter including your motivation and qualification for the applied position - Attach a recent CV with a full list of publications and patents - Send separate application packages for each position that you are applying for. - Website: https://pharmcadd.com/ - Application due date: 30th SEP 2022NOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!
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|Modified: Wed Mar 30 14:46:00 2022 GMT|
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