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Up Directory CCL 20.03.04 Senior (Principal) Molecular Modeler
From: jobs at ccl.net (do not send your application there!!!)
To: jobs at ccl.net
Date: Wed Mar 4 09:57:29 2020
Subject: 20.03.04 Senior (Principal) Molecular Modeler
Pleased to meet you, we are Galapagos, a dynamic fast growing biotech
company with offices in Europe, in Belgium (Mechelen), France
(Romainville), the Netherlands (Leiden), Switzerland (Basel) and in the
US (Boston).

Were in the business of changing lives. In our quest to discover and
develop life-improving medicines we go where no one has ever gone
before. In every challenge we face, we see new opportunities. We want to
challenge the impossible. We need thought leaders and rapid thinkers,
entrepreneurs in spirit and status quo-fighters. Collaborative
innovators and perseverant idealists, we need the best-in-class. In
other words, we need you: The make-it-happeners.

 

We are looking for a Senior/Principal Molecular Modeler (Computational
Chemist) - Mechelen,BE

 

Scope of the job

As member of the Molecular Modelling & Design team (part of the
Computational Research group, 8 people), your primary responsibility
will be the judicious application of computational methods to the
discovery and optimization of drug candidates.

You will be involved in structure-based (SB) and ligand-based (LB) drug
design, compound selection and acquisition, HTS data analysis and
triage, virtual screening, statistical modelling, and ADMET prediction.
You will be working closely with medicinal chemists, biologists, DMPK
scientists and other project team members to define and achieve project
goals.

You will also have the opportunity to participate in evaluating,
developing, implementing and applying new computational methodologies
and strategies. You will identify areas of scientific improvement within
computational sciences and their potential for application to projects.
You will contribute to the development of new computational capabilities
and maintain an up to date awareness of recent literature and current
developments within the field.


Who are you?

-A Ph.D. degree followed by at least 3 years of experience in
computer-aided support to drug discovery projects in a
multi-disciplinary project team. Experience in an industrial setting
would be an advantage.

-Expertise in structure- and ligand-based drug design

-A good background in organic chemistry and a solid knowledge of
medicinal chemistry concepts


Required skills:
-Programming, scripting and/or query languages (such as Python, SQL)

-Good knowledge of Linux and awareness of the latest hardware and cloud
solutions

-Knowledge of drug target families (kinases, GPCRs, proteases, PDEs)

-Strong experience in common molecular modelling techniques (protein
homology modelling, docking, pharmacophore modelling, target- and
ligand-based virtual screening)

-Strong expertise in at least one of the following techniques: ADMET and
physicochemical property prediction, machine learning, molecular
simulations (MD), FEP, quantum mechanics calculations

-Experience with data-workflow tools (such as Pipeline Pilot or Knime)

Whats in it for you?

You will be part of a fast growing and amazing company. You will get all
the support you need to make your job successful. At Galapagos we aim to
recruit the best people, who stand out among their peers, with integrity
and excellent interpersonal and organizational skills. Our employees are
the strength behind Galapagos, a highly motivated team, eager to
maintain Galapagos leading position and achieve breakthroughs in
pharmaceutical research. Galapagos offers a competitive remuneration
package and a dynamic work environment.

We are Galapagos: together we can make it happen!
You can mail your cv to our Talent Acquisition team:
   wim.vanhaele-ext%x%glpg.com
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Modified: Thu Mar 5 04:23:48 2020 GMT
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