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To: jobs at ccl.net
Date: Thu Feb 27 11:24:18 2020
Subject: 20.02.27 Associate Principal Scientist: Computational Chemistry, AstraZeneca, Sweden
Associate Principal Scientist: Computational Chemistry, AstraZeneca, Sweden
Location Gothenburg, Västra Götaland County, Sweden
Job ID R-074297
Date posted 02/13/2020
Do you want to join a world leading team in developing the next generation
of respiratory medicines?
AstraZeneca R&D, Gothenburg, Sweden seek to recruit an Associate Principal
Scientist, Computational Chemistry, in the area of Respiratory,
Inflammation & Autoimmunity (RIA)
AstraZeneca is committed to the development of the next generation of
innovative respiratory medicines. The Computational Chemistry team leads
efforts to expand the use of state of the art in silico methods for
modelling, ligand design, property predictions and data analysis
supporting the RIA drug discovery projects with a focus on small to medium
sized molecules. The team operates in a highly cross disciplinary
environment in close collaboration with scientists from the Chemistry,
Bioscience, DMPK and Pharmaceutical Sciences departments to advance the
RIA project pipeline.
As a Computational Chemist you will have a profound impact on multiple
projects across the RIA portfolio. You will work collaboratively with
medicinal chemists and multidisciplinary teams to design compounds with
improved potency, selectivity, activity and/or ADME properties. By working
simultaneously across multiple projects (2-3), in all discovery phases,
you will identify and drive ligand design strategies and efficiently and
proactively apply a full range of drug design and computational chemistry
approaches to manage complex problems within a project, delivering results
to timelines that impact the design of compounds for synthesis and testing.
You will be accountable for identifying areas of scientific improvement
within computational sciences and their potential for application to
projects within AstraZeneca and you will contribute to the development of
new computational capabilities at AstraZeneca through collaboration with
external groups or colleagues at other AstraZeneca sites. You will publish
original work and literature reviews in peer reviewed journals and at
conferences, maintaining an up to date awareness of recent literature and
current developments within the field.
We are seeking an engaged computational chemist with a PhD in
computational chemistry, chemistry, pharmacology, or a related field with
strong computational background. Industry experience or a track record of
applying innovative solutions with resulting impact in drug discovery
project delivery is a plus, but not a must. The candidate is encouraged to
have a high degree of independence and to be an expert in a number of
computer-aided drug design techniques to assist target identification and
advancement of discovery programs.
Requirements and Qualifications
- Solid knowledge of computational chemistry and medicinal chemistry concepts.
- A detailed understanding of how computational chemistry contributes to our
drug discovery projects together with a sound understanding of the drug
discovery process encompassing other disciplines, such as synthetic,
structural and medicinal chemistry, DMPK, structural biology, biophysics,
biological science etc.
- Experience and expertise in structure-based and ligand-based design
techniques is essential, knowledge in scientific computing, and
programming skills (e.g. Python, Perl, C, C++, Java) are desired.
- Specific knowledge in molecular dynamics (MD) applications with a track
record of applying these techniques to relevant problems in the field is
- Strong written and interpersonal skills and ability to work well in
multidisciplinary project teams
- Excellent time management skills, forward planning and delivery focus
For more information about this position please contact: Dr. Christian
Tyrchan, Medicinal Chemistry, IMED RIA,
Please apply on line no later than March 20th, 2020 at
AstraZeneca embraces diversity and equality of opportunity. We are
committed to building an inclusive and diverse team representing all
backgrounds, with as wide a range of perspectives as possible, and
harnessing industry-leading skills. We believe that the more inclusive we
are, the better our work will be. We welcome and consider applications to
join our team from all qualified candidates, regardless of their
characteristics. We comply with all applicable laws and regulations on
non-discrimination in employment (and recruitment), as well as work
authorisation and employment eligibility verification requirements.
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