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Date: Tue Jan 28 17:57:11 2020
Subject: 20.01.28 Postdoctoral Fellow, Computational Antibody Engineering (Montreal, Canada)
Postdoctoral Fellow, Computational Antibody Engineering

Postdoctoral Fellow, Computational Antibody Engineering
National Research Council Canada

City: Montreal
Organizational Unit: Human Health Therapeutics
Classification: RO
Tenure: Term
Duration: 2 years
Language Requirements: English or French

The NRC Advantage


The National Research Council of Canada (NRC) is the Government of Canada's largest research organization supporting industrial innovation, the advancement of knowledge and technology development. We collaborate with over 70 colleges, universities and hospitals annually, work with 800 companies on their projects, and provide advice or funding to over 8000 Small and Medium-sized Enterprises (SMEs) each year.

We bring together the brightest minds to deliver tangible impacts on the lives of Canadians and people around the world. And now, we want to partner with you. Let your expertise and inspirations make an impact by joining the NRC.

At NRC, we know diversity enables excellence in research and innovation. We are committed to a diverse and representative workforce, an open and inclusive work environment, and contributing to a more inclusive Canadian innovation system.

NRC welcomes all qualified applicants and encourages candidates to self-declare as members of the following designated employment equity groups: women, visible minorities, aboriginal peoples and persons with disabilities.

Please advise of any accommodation measures required to enable you to be assessed in a fair and equitable manner. They are available to all candidates for further assessment. Related information received will be addressed confidentially.

The Program

The NRC's Postdoctoral Fellowship program offers PDFs access to unique world-class facilities and the opportunity to work alongside multi-disciplinary teams of expert researchers and technicians on projects of critical importance to Canada. PDFs will carry out research on innovative research projects, with opportunities for career development (publications and/or industry interaction).

PDFs will be offered appointments to the staff of the National Research Council on a term basis and will be offered salaries and benefits currently available to Research Officers. Salaries commensurate with experience are taxable and subject to other deductions. As a guide, the current annual PhD recruiting rate is $72,053. In addition PDFs will be allocated a travel fund to support their work.

Project Title

Hooked on pHomics: Improving safety of the global pipeline of anticancer biotherapeutics by ADAPTation to acidic microenvironments

Your Challenge

Recent development of monoclonal antibodies as mainstream anticancer agents demands further optimization of their safety for use in humans. Their target antigens overexpressed by cancer cells are also present in normal tissues, which may lead to unwanted toxicity. In this project, using molecular structure database mining and computational screening methods, hundreds of biologics from the current global anti-cancer pipeline will be adapted for preferentially engaging their targets under the acidic microenvironment of the tumor, thus sparing normal cells. Optimized molecules for the most urgently needed treatments will be validated experimentally.

Although the PDF will initially use our ADAPT computational platform for in silico structure-based pH-selectivity optimization, he/she will be encouraged to contribute ideas and carry out independent research to improve its efficiency and accuracy. The successful PDF candidate will be embedded in the NRC's Molecular Modeling Team, which promotes a culture of innovation and cross-fertilization of ideas.


PhD in Computational Chemistry, Molecular Modeling, Biochemistry or a related field.

For information on certificates and diplomas issued abroad, please see Degree equivalency.


  • Scientific programming/scripting in Linux using one or more general-purpose languages (e.g., C/C++, R, python, bash, awk, etc).
  • Track record in structure-based drug design and optimization, preferably antibody-antigen complexes.
  • Familiarity with computational methods for conformational sampling, ionization equilibria and pKa calculations, grounded on an understanding of the theory behind these methods.

Language requirements

English or French

Information on language requirements and self-assessment tests

Condition of Employment

Reliability Status

Who is eligible?

  • Fellowships will be for two years contingent on satisfactory progress achieved during the first year.
  • Candidates should have obtained a PhD (or equivalent) within the past three years (PhD received on or after July 1, 2017) or expect to complete their PhD within 6 months of appointment.
  • Fellows will work in a lab under the direct supervision of an NRC researcher.

Although preference will be given to Canadian citizens and Permanent Residents, Fellowships are open to nationals of all countries. The offer of a Fellowship does not ensure foreign nationals Permanent Residency in Canada. Non-Canadian candidates should apply for non-immigrant status (i.e. temporary status) and an employment visa. For further information, please contact the closest Canadian High Commission, Embassy or Consulate in your area.

Application Requirements

In order to be considered for the program please include the following in your application, please note that you will need to attach the required documents as per the list below when submitting your application. Failure to do so will result in your application being excluded from searches.

  • Resume
  • Statement of Interest in the project (maximum one page in length)
  • PhD Transcript - an electronic copy is sufficient, it does not have to be an official version.
  • List of Publications

When submitting your application you can include the required documents in any attachment field such as "Second language evaluation results" or "Other attachments".

In addition, applicants who best meet the requirements of the position will be asked to provide three letters of recommendation at a later stage of the competition process.


Relocation assistance will be determined in accordance with the NRC's directives.

Salary Range

From $55,541 to $157,009 per annum.

The Postdoctoral Fellowships Program is unique to the NRC. It falls under the RO/RCO classification system which uses a person-based classification system instead of the more common duties-based classification system. Candidates are remunerated based on their expertise, skill, outcomes and impacts of their previous work experience.


  • NRC employees enjoy a wide-range of benefits including comprehensive health and dental plans, pension and insurance plans, vacation and other leave entitlements.
  • Fellowships are open to nationals of all countries, although preference will be given to Canadian Citizens and Permanent Residents of Canada. Please include citizenship information in your application.
  • The incumbent must adhere to safe workplace practices at all times.

Please direct your questions, with the requisition number (9610) to:
E-mail: NRC.NRCHiring-EmbaucheCNRC.CNRC[A]
Telephone: 613-949-7685
Closing Date: 18 March 2020 - 23:59 Eastern Time

Apply now

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