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Up Directory CCL 19.12.19 Postdoc Fellow - Cryo-EM based molecular dynamics and modelling, AstraZeneca, Boston
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Date: Thu Dec 19 11:41:36 2019
Subject: 19.12.19 Postdoc Fellow - Cryo-EM based molecular dynamics and modelling, AstraZeneca, Boston
Postdoc Fellow - Cryo-EM based molecular dynamics and modelling
Location Waltham, Massachusetts, United States 
Job ID: R-064327

AstraZeneca is a global, innovation-driven biopharmaceutical business that
focuses on the discovery, development and commercialization of prescription
medicines for some of the worlds most serious diseases. We're proud to have
a unique workplace culture that inspires innovation and collaboration. We 
believe in the potential of our people and youll develop beyond what you 
thought possible.

The new R&D Oncology organization brings together early and late oncology 
teams, from discovery through to late-stage development, with oncology 
specific Regulatory and Biometrics groups.

You'll be in a global pharmaceutical environment but also exposed to strong 
rigorous academic science. For example, every postdoc has an external 
academic mentor to ensure we are working and publishing at the highest 
level in a field. Whats more, youll have the support of a leading academic 
advisor, wholl provide you with the guidance and knowledge you need to develop 
your career.

At AstraZeneca we believe in the potential of our people and you'll develop 
beyond what you thought possible. We make the most of your skills and passion 
by actively supporting you to see what you can achieve. We need great people 
who share our passion for science and have the drive and determination to 
meet the unmet needs of patients around the world. If youre curious about 
what science can do, then youre our kind of person.

You'll have the opportunity to combine advanced molecular modelling and molecular 
dynamics methods with cryo-EM density maps to provide unparalleled understanding 
the structure and conformational flexibility of biomolecules which cannot be 
crystallized. Multiple computational approaches have been utilized externally, 
but there is no best practice yet defined, so this is an opportunity to work 
with a multidisciplinary team of experts push the science forward and apply new 
hybrid methods to both published and proprietary AZ datasets. Ultimately, this 
work should enable identification of new small molecule binding sites to modulate 
future drug targets of interest.

You'll be responsible for working independently to develop and evaluate methods 
to enhance medium-resolution cryo-EM structures with additional atomic detail, 
and characterize these further with molecular dynamics simulations, trajectory 
analysis, and interpretation to help the understanding the role of conformation 
on the activation and regulation of the human ATM enzyme kinase. This project 
will be supported by experienced computational chemists and experts in cryo-electron 
microscopy, and the Postdoc will update and seek input from the group at regular 
project meetings, and will present the research to the wider community of 
AstraZeneca computational chemists, postdoc groups, and the senior leadership 
team, as well. You'll further be responsible for the planning and writing of 
manuscripts reporting their results, aiming for high-impact journals.

Education and Experience required:


Doctorate degree in the area of computational chemistry, with relevant experience 
in biophysical chemistry and carrying out molecular dynamics simulations of proteins 
with software such as DESMOND, AMBER, or GROMACS, working experience with molecular 
modelling based on cryo-EM density maps.


Experience with programming languages, such as python and C.

Skills and Capabilities required:

Scientific independence, with excellent time management skills, professionalism in 
the workplace, forward planning and delivery focus.

Working experience of molecular modelling based on cryo-EM density maps.

Molecular dynamics and enhanced sampling techniques with large protein systems.

Strong written and oral communication skills and ability to work well in 
multidisciplinary teams.

Demonstrated track record of scientific publication.

This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year 
extension which will be merit based.  The role will be based in Waltham, US with 
a competitive salary on offer. To apply for this position, please click the apply link below.
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