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Up Directory CCL 19.12.17 Postdoctoral position in Computational Biochemistry
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Date: Tue Dec 17 05:57:50 2019
Subject: 19.12.17 Postdoctoral position in Computational Biochemistry
Uppsala University is a comprehensive research-intensive university with a strong international 
standing. Our mission is to pursue top-quality research and education and to interact constructively 
with society. Our most important assets are all the individuals whose curiosity and dedication 
make Uppsala University one of Swedens most exciting workplaces. Uppsala University has 
44.000 students, 7.100 employees and a turnover of SEK 7 billion.

The Department of Chemistry  BMC is located at the Uppsala Biomedical Centre campus. 
It belongs to the Faculty of Science and Technology and conducts research in biochemistry, 
organic chemistry and analytical chemistry. The research is focused on catalysis, molecular 
recognition, structure and dynamics of complex molecular systems, and relationships between 
the presence of biomolecules and synthetic chemical compounds with various disease states. 
The creative and research-intense environment contributes to a broad knowledge-base as 
well as cutting-edge expertise.

The Kamerlin group seeks up to two postdoctoral researchers to join our team.

We are an international and interdisciplinary team of dedicated scientists who come from 
different backgrounds to study biochemical problems such as enzyme evolution, and 
structure-function-dynamics relationships in biomolecular systems, as well as fundamental 
problems in physical organic chemistry, using a range of advanced computational tools. 
Where relevant to solving problems of interest to us, we also engage in methodology 
development. These positions are funded by a range of sources including the Swedish 
Research Council and the Knut and Alice Wallenberg Foundation. The focus of the work 
will be on using computational tools to understand and guide the evolution of new enzyme
functions, as well as the role of ligand-gated conformational changes in enzyme catalysis. 
More details about our team, and our research interests, can be found on the lab website:

Duties: Full time research, mentorship of junior researchers, and, for interested candidates, 
the possibility of teaching duties (up to 20%). The position will also include international 
travel to conferences and meetings with collaborators. From a scientific perspective, this 
position will involve computational integration of simulation and experimental data using 
a range of molecular simulation tools, including both standard and enhanced molecular 
dynamics simulations, empirical valence bond and QM/MM simulations, free energy 
calculations, structural bioinformatics and machine learning techniques.


PhD in a STEM discipline with a strong background in computational chemistry and/or
computational biology, with experience in one or more of the techniques used in the Kamerlin 
lab (see Duties, above). The PhD degree should have been obtained within three years of the 
final application date. The three-year period can be extended on special circumstances, such 
as prolonged periods of illness, parental leave, military service, union duties and others of 
similar character.

Either: (1) experience in modeling enzyme reaction mechanisms and/or enzyme function-dynamics 
relationships, in particular in the context of understanding enzyme evolution, or (2) experience in 
using enhanced sampling approaches (such as replica exchange or metadynamics) to study 
biomolecular systems, with particular preference given to studies of the role of conformational 
dynamics in enzyme engineering or evolution.

Excellent communication skills in written and spoken English, as well as publications of a high 
scientific standard (assessed according to the DORA principles, see

Good collaborative skills, such as working with others or in a team.

Emphasis will also be placed on personal skills. In this case, we place particular weight on the 
ability to work as part of a team and a positive attitude towards mobility. The applicant will be
responsible for a part of a larger project, and the ability to work independently and to take 
responsibility will be required.

Additional Desirable Skills: Programming skills and/or expertise in structural bioinformatics, 
statistical mechanics or machine learning approaches to study enzyme function and/or evolution.

Application: The application must include a CV, full publication list, copies of diplomas and 
certificates, contact details of two references, and a personal letter including a short description 
of research interests. The application will be evaluated based on the following criteria: Appropriate 
education and work/research in related fields. Emphasis will also be placed on personal skills.

Uppsala University strives to be an inclusive workplace that promotes equal opportunities and 
attracts qualified candidates who can contribute to the Universitys excellence and diversity. 
We welcome applications from all sections of the community and from people of all backgrounds.
Full details of the listing, as well as a link to the application portal, can be found here:

Applications should be made through the online portal at the link above.

Please do not submit your application by email, the University does not accept it.

For questions about the position, please contact Lynn Kamerlin: lynn.kamerlin[at]
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