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Date: Sat Dec 7 22:55:32 2019
Subject: 19.12.07 Computational Chemist/postdoc in Structure-Based Drug Design, University of Kentucky, Lexington, KY

Computational Chemist/postdoc in Structure-Based Drug Design, University of Kentucky, Lexington, KY

Computational chemist or postdoc position(s) in structure-based drug design, supervised by Dr. Chang-Guo Zhan ( http://pharmacy.uky.edu/faculty/czhan6 ), are available in two multi-disciplinary research centers (Molecular Modeling and Biopharmaceutical Center and Center for Pharmaceutical Research and Innovation) at College of Pharmacy, University of Kentucky.

Drug candidates designed and discovered in Dr. Zhan's lab/centers include both small molecules and proteins (particularly therapeutic enzymes or antibodies). The computational chemist/postdoc will be involved in multiple drug discovery and development projects, responsible for the computational modeling and drug design. The computational design is followed by wet experimental tests in vitro and in vivo. These experiments are performed either in Dr. Zhan's lab or in a close collaboration with internal and/or external experimental laboratories. Our unique structure-and-mechanism- based drug design and discovery efforts through integrated computational- experimental studies (supported by the NIH, NSF, DoD, VA, and other organizations) have been very productive, leading to exciting discovery of novel, promising therapeutics. Phase II human clinical trials have been completed for two of the therapeutic agents designed by us; one has received the Breakthrough Therapy Designation by the FDA. The members of Dr. Zhan's lab work in an interdisciplinary research environment. More detailed information about Dr. Zhan's lab and the research centers:
http://pharmacy.uky.edu/faculty/czhan6;
http://pharmacy.uky.edu/research-innovation-and-discovery/research-centers/molecular-modeling-and-biopharmaceutical-center;
http://pharmacy.uky.edu/research-innovation-and-discovery/research-centers/cpri;

Applications/inquiries should be sent to Dr. Zhan at zhan]*[uky.edu . The applications/inquiries should include:

  • CV with a list of publications and contact details for at least two reference persons;
  • A short letter describing your interest to work in the field of computational modeling and drug design.

Applications will be reviewed immediately and will continue until the position(s) are filled.



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