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Date: Fri Dec 6 10:07:38 2019
Subject: 19.12.06 Computational Chemist, Drug Discovery Unit, CRUK Beaston Institute, Glasgow, UK
Salary Range 30,000 to 41,000 (British pounds) depending on experience

3 year contract

The Drug Discovery Unit at the Beatson Institute in Glasgow (UK), 
is one of four Cancer Research UK funded Drug Discovery Units 
across the UK. The aim of these units is to work closely with 
local cancer experts to maximise the opportunity to develop new 
and innovative therapies that strike at the core of cancer pathology. 
Using state of the art screening, advanced structural biology, 
industry standard computational and medicinal chemistry and 
complex biological modelling systems, the Drug Discovery group at 
the Beatson is tackling some of the most challenging targets in 
cancer biology today. One such target that has eluded drug discovery 
efforts over the years is KRAS.  Highly mutated in cancer, 
KRAS has proved difficult to target. Harnessing the significant 
capability of the Beatson Drug Discovery Unit we have developed a 
highly competitive KRAS inhibitor project. 

An exciting opportunity has arisen within the Beatson Drug Discovery 
Unit to join a three year collaboration project with Novartis 
to develop RAS inhibitor compounds for the treatment of KRAS driven 
cancers for which there is a substantial unmet clinical 
need. This project builds on the success within the BDDU in developin
g KRAS inhibitors and we are now looking for an enthusiastic 
computational chemist to join our team to take this project
to the next stage.  The successful candidate will primarily 
support the advancement of current oncology projects within the DDU 
through mainly structure-based computational approaches. 

The candidate should have a sound knowledge of programs
(such as MOE, Schrodinger, Molsoft and ADMET Predictor) and 
computational techniques, data visualization (e.g. Dotmatics Vortex) 
and pipelining tools (e.g. PipelinePilot, Knime) used in an 
industry-standard drug discovery setting.

Skills and Experience:

Ph.D. in computational chemistry, cheminformatics or a 
related field

Demonstrated skills in the application of computer-assisted 
drug design using modelling and computational software

Experience in applying quantum mechanics, molecular dynamics 
and free energy perturbation calculations in drug design desirable

Experience of working  within a drug discovery environment 
would be an advantage 

Strong oral and written communication skills required

Communicate and collaborate effectively with medicinal chemists,
structural biologists and other members of cross-functional project 

Excellent knowledge of at least one programming or 
scripting language (such as Python, Java, C++ and R)

Good knowledge of UNIX/Linux, queueing systems and cloud computing 

Ability to work independently and collaboratively in a 
multidisciplinary, team-oriented environment 

Maintain and develop working knowledge of state-of-the-art 
computational chemistry methods and their application to drug design

Basic knowledge of medicinal chemistry preferred
Informal enquiries are welcome and should be addressed to 
Dr Justin Bower (Joint Head of Drug Discovery)

All applications must be made via our website at

Closing date for applications is 10th of January 2020
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Modified: Fri Dec 6 15:07:38 2019 GMT
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