|CCL 19.07.08 Postdoctoral Opening, Multi-State Protein Modeling - Keedy Lab, NYC|
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Date: Mon Jul 8 13:01:38 2019
Subject: 19.07.08 Postdoctoral Opening, Multi-State Protein Modeling - Keedy Lab, NYC
The Daniel Keedy Lab at the CUNY Advanced Science Research Center in New York City has an available position for a Postdoctoral Researcher, funded by the National Institutes of Health. The Keedy Lab aims to elucidate the conformational ensembles of proteins and to understand how they are shifted by perturbations, including mutations, protein:protein interactions, and ligands, to control function. We are especially interested in how hidden conformational ensembles drive differences in allosteric regulatory mechanisms for protein tyrosine phosphatases (PTPs), which are under-studied but biologically critical. To explore these questions, we are developing new multi-state modeling algorithms that exploit series of X-ray crystallographic datasets related by temperature, pressure, etc. to reveal particular conformational states and the transitions between them. We are also interested in marrying such approaches with rational multi-state computational design to engineer proteins with novel allosteric functionalities. The CUNY Advanced Science Research Center is a new cutting-edge research institution located in upper Manhattan in New York City -- the "greatest city in the world". The Structural Biology Initiative of the ASRC features seven tenure-track and research-track faculty members, pursuing diverse research problems using X-ray diffraction, cryo-EM, NMR, mass spectrometry, solution biophysics, and advanced microscopy. The ASRC has shared access to the CUNY High-Performance Computing Center, and will also enjoy a new dedicated high-performance computing cluster equipped with GPU nodes starting this fall. The ASRC is also immediately adjacent to the New York Structural Biology Center, a consortium of CUNY and eight other New York academic institutions with world-class facilities, and 70 miles from Brookhaven National Laboratory, featuring the newly constructed National Synchrotron Light Source II, now the brightest synchrotron light source in the United States. For more information, visit our newly designed lab website: https://keedylab.org Candidates should have expertise in computational biophysics or related areas. Experience writing or contributing to scientific software is significantly preferred. Experience with either computational of experimental aspects of crystallography is preferred but not required. This position is available starting immediately, though the start date is flexible. To apply, please contact Dr. Keedy directly at daniel.keedy*asrc.cuny.edu with a CV and brief description of your interests. You may also officially apply to a position in the lab here: https://cuny.jobs/new-york-ny/research-associate-structural-biology-initiative/3F61F1DE234B4BF7BA9E5777089B982C/job/NOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!
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