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Up Directory CCL 19.03.07 Computational Chemist, C4X Discovery, Manchester/London, UK
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Date: Thu Mar 7 07:54:50 2019
Subject: 19.03.07 Computational Chemist, C4X Discovery, Manchester/London, UK
C4X Discovery is currently looking to extend its drug discovery team with 
experienced, highly motivated Computational Chemist. This role is 
office-based and can be undertaken from either our Manchester or London 

Working as part of a team of scientists, this role combines the knowledge 
and expertise of a traditional Computational Chemist with C4Xs 
conformational insights from its NMR technology to design novel small 
molecules with the view to optimise them to drug candidates.

This role offers the opportunity to shape the use of cutting-edge drug 
discovery approaches, focussed on driving quality in drug discovery.

Were looking for enthusiastic and experienced Computational Chemists to 
integrate experiment based conformational analysis into drug design and 
to influence the use of conformational information in medicinal chemistry 
approaches. Contribution to efforts of integrating multiple threads of 
experimental data in commercial software (Schrodinger and CCDC Suites) as 
well as newly developed, in-house tools are a feature of this role.

The main responsibilities will include utilising experimentally 
determined conformational data to aid the evaluation of SAR data and 
hypothesis driven design, to drive structure-based design, support 
projects with hit finding strategies including ligand-based Virtual 
Screening, to expand the C4X knowledge base of conformational drivers, 
and to embed novel and creative working practices in computational and 
medicinal chemistry.

To succeed in this position, you will also require a high, proven level 
of self-motivation, flexibility and organisational skills. The role forms 
a key part in C4X Discoverys Discovery team.

We are looking for candidates with a PhD and significant industry 
experience (5+ years), including experience in project support, use of 
computational packages, structure and ligand-based design, in silico 
conformational analysis techniques (such as QM, MD), and 
ChemInformatics/Data analysis.

Experience with scripting (in Python, for example), Machine Learning, 
use of RDKit and collaboration with third parties including CROs would 
be an advantage.

C4X Discovery offers a broad selection of health benefits, share options, 
a generous pension scheme and an annual, discretionary bonus scheme.
Please send a CV & cover letter to jobs^

For a full job description and person specification, visit where you will also find more information on the 
C4XD Drug Discovery Engine business model and details on how your 
personal data will be handled throughout the recruitment process.
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