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Date: Thu Oct 18 11:42:23 2018
Subject: 18.10.18 Senior Scientist - CADD - UCB Slough/Belgium/US
At UCB everything we do starts with a simple question: How will this
make a difference to the lives of people living with severe diseases? We do
that by connecting with patients and their families around the world living
with the physical and social burdens of severe disease of the immune system
and the central nervous system. Those connections offer new perspectives,
drive innovation, and offer the hope of a new generation of therapies that
will help to transform lives. 

Role Overview
We are seeking an exceptional candidate to join our Computer-Aided Drug
Design (CADD) team within Global Chemistry to drive the discovery of new
therapeutic candidates using targeted protein degradation. 

This position can be located either in our UK research site in Slough, our
Belgian research site in Braine-l'Alleud or our US research site in Bedford,

Primary Responsibilities
Independently design and execute computational experiments in a timely manner
to drive the application of targeted protein degradation technology to
therapeutic projects.

Be proactive in anticipating project needs, contributing strategy and driving
project progression from target evaluation to lead-optimisation.

Drive innovation and new technology, bringing in external science and
methodology and developing new ways of working internally at UCB.

Contribute to scientific discussions and present data at internal meetings
and external scientific conferences.

Contribute to the maintenance of a safe and effective working environment by
setting high personal standards and complying with all Company HSE codes of

Create effective working relationships within the global chemistry and UCB
matrix working environment via influencing and networking.

Demonstrate high level of entrepreneurship and foster a can-do and can-win

Drive own professional development for continuous improvement of knowledge
and skills. Mentor less experienced colleagues. Help to create a teamwork

Essential Requirements
A PhD in molecular modelling or a related field is required with a good
publications track record.

Experience of structure-based or ligand-based small molecule design.

Experience in programming languages such as C++ and/or Python.

Ability to communicate effectively in English, both verbally and in writing,
and skilled in communicating scientific concepts through data visualization. 

Desired skills and experience
- Experience in drug-ability and target evaluation.
- Experience in targeted protein degradation.
- Application of advanced statistics.
- Knowledge of advanced molecular simulations approaches (examples of these
  packages are AMBER, GROMACS, ACEMD, NAMD, SIRE, Plumed, Desmond) and
  examples of applications to protein-ligand and protein-protein binding.
- Development of advanced cheminformatics protocols using KNIME/PipelinePilot
  or coding toolkits such as RDkit, CDK or OpenEye.
- Understanding of modern medicinal chemistry.
- Familiarity with screening and assay design.
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