The Computational Drug
Design Group (Gloriam group), Department of Drug Design and Pharmacology, University
of Copenhagen, wishes to employ a 2,5-year
postdoc in Computational Drug Design or Computational Chemistry. The position starts 1. October 2018 or soon
thereafter (latest Jan 1st) and lasts for 2,5 years.
The Gloriam group (www.gloriamgroup.org)
conducts computational drug design, tightly integrated with leading chemists
and pharmacologists, and structure-function studies of G protein-coupled
receptors (GPCRs) one of the largest drug target families. The group also heads
the GPCR communitys main database and web server, GPCRdb (GPCRdb.org) serving
~2500 monthly users. The group currently has 15 members, funded mainly by an
ERC Starting Grant and Lundbeck Foundation Fellowship, and has in the last
two years published in e.g. Nature, Cell,
Nature Reviews in Drug Discovery, Nature Chemistry and Nucleic Acids Research.
The project aims to
identify and optimise selectivity inhibitors of G proteins that will serve as
important probes to dissect receptor signalling pathways and to design
drugs/ligands with pathway-selectivity (aka. biased agonism). Most inhibitors
will be derived by designing peptides from protein-protein complexes, and
increasing their stability and membrane permeability. The project may also include
small molecule virtual screening.
You have a solid experience
in computational drug design / computational chemistry and an interest in
scripting. You are motivated by working in interdisciplinary project teams,
identifying ligands/probes to increase our understanding of human biology,
and solving challenging problems by independently and quickly learning new
knowledge, techniques and correlations. You are a good team player, and will
have the opportunity to work together with experienced computational drug
designers; as well as to supervise students.
A PhD in
computational chemistry or similar topic
of computational ligand identification and optimisation
experience of scripting/programming
ability to independently learn new concepts and solve biological problems
in English and demonstrated ability to write scientific texts
Experience of, and
Schrdinger Drug Discovery Suite and PyMOL
scripting, programming in Python or other languages
Key criteria for the assessment of
The key criteria will be the strength of the applicants CV.
qualifications relevant to the project
Relevant work experience
Good interpersonal skills
General job description
tasks as a Post Doctorial fellow at the Faculty are to:
and carry through your research project
Write scientific articles
Participate in the education and guidance of students
Terms of employment
The post will be filled
according to the Agreement between the Danish Ministry of Finance and the
Danish Confederation of Professional Associations. The post is covered by the
Protocol on Job Structure.
information about the post, please contact Associate Professor and Group
Leader David E. Gloriam via david.gloriam%%sund.ku.dk or (+45) 93 56 54 49.
The application, in
English, must be submitted in the online application form at https://employment.ku.dk/faculty?show=147583.
The application must include the following appendices:
curriculum vitae with documentation of education.
Appendix 2: a
complete list of publications and list of submitted appendices.
documentation of additional research qualifications.
In addition to the
material the applicant wishes to be included in the assessment, the
Assessment Committee may include further material in their assessment of the
applicant, such as reference letters. In such circumstances, it is the
responsibility of the applicant, on request, to send the material to the
Committee. No research/project plan needs to be submitted. Following
processing of the application, any application material sent will be
The applicant will
be assessed according to the Ministry of Science Technology and Innovation
Executive Order no 284 of 25. April 2008.
University of Copenhagen and Denmark
Founded in 1479, the University of Copenhagen is the oldest university in
Denmark. With 37,000 students and 9,000 employees, it is among the largest
universities in Scandinavia and one of the highest ranking in Europe. The
University consists of six faculties, which cover Health and Medical
Sciences, Humanities, Law, Science, Social Sciences and Theology. Read more
at www.sund.ku.dk and www.drug.ku.dk.
is a modern capital with plenty of opportunities in culture, design,
architecture, restaurants and a diverse nightlife. At the same time, the city
offers beaches, beautiful parks and green nature areas, and the Copenhageners
bike everywhere. The Danish society prioritises a good work-life balance, and
the work culture is well adjusted for families with children. Read more at