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Up Directory CCL 18.01.24 PhD/Postdoc positions based in Shenzhen-China in XtalPi co-invested by Sequoia, Google, Tencent
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To: jobs at ccl.net
Date: Wed Jan 24 13:38:19 2018
Subject: 18.01.24 PhD/Postdoc positions based in Shenzhen-China in XtalPi co-invested by Sequoia, Google, Tencent

A Number of Positions Available at XtalPi, Inc. in China

About Xtalpi
XtalPi Inc., a computation-driven pharmaceutical technology company, announced today that it has closed a Series B funding round of 15 million USD led by Sequoia China, with participation from Google and existing investor Tencent. To date, XtalPi has raised over 20 million USD, making it one of the top-funded AI-powered biotechs.
XtalPi offers Intelligent Digital Drug Discovery and Development (ID4) that improves the efficiency, accuracy, and success rate of drug design, solid-form drug selection, and other critical aspects of preclinical drug development. In combining artificial intelligence, quantum physics, and high-performance cloud computing, XtalPi can quickly and accurately predict many important characteristics of small-molecule drugs and solid forms, thereby providing time-saving insights into the safety, stability, and efficacy of drug candidates. XtalPi's existing investors also include ZhenFund and FreeS Fund. It currently partners with top global pharmaceutical companies and research organizations and looks forward to expanding industry collaborations with both existing and new partners.

Contact information:
Wechat: lidanhui_Grace
Telephone: (86)0755-86931536
Send your resume to Email: szhr^^^xtalpi.com
Subject: your name + degree + position

Positions as below:



Scientist for Drug Property Prediction

SDPP will join our research team that includes tens of PhDs and collaborate with our cloud computing and AI experts to work on the prediction of molecular properties of drugs, algorithm implementation and method development.

Responsibility

  • Design and test protocols to predict thermodynamic properties such as free energy, solvation and drug-target interaction
  • Design and test protocols to predict properties of drug molecules in various states
  • Develop and test new force field with force field developers

Qualifications

  • Master or PhD in quantum chemistry, physical chemistry, medicinal chemistry, condensed matter physics, computational materials or related sciences
  • Experience with prediction of thermodynamic properties based on thermodynamic integration or free energy perturbation
  • Excellent programming skills, familiar with at least one programming language (Python, C, C++,Fortran, Java, etc.)
  • Good communication skills, team player and be self-motivated
  • Excellent English reading and writing skills

Desirable skills

  • Experience with simulation of bio-molecules, quantum chemistry, and medicinal chemistry
  • Experience with development of molecular force field
  • Experience with application and development of enhanced sampling methods


Senior Computational Chemistry Scientist

Responsibility

  • Work with IT engineers to build and analyze drug-like molecule database
  • Predict Drug-like properties of molecules based on quantum chemistry
  • Develop and test software, algorithms and platforms

Qualifications

  • Master or PhD in quantum chemistry, physical chemistry, medicinal chemistry, condensed matter physics, computational materials or related sciences
  • Minimum three-year experience with quantum chemistry software suites, familiar with at least one development language and have a good knowledge of the science behind the software
  • Knowledge of QSAR
  • Excellent programming skills, familiar with at least one programming language (Python, C, C++, FORTRAN, Java, etc.)
  • Good communication & interpersonal skills, team player and be self-motivated
  • Good English reading and writing skills

Desirable skills

  • Experience with drug-like molecule database
  • Experience with simulations based on molecular force field
  • Experience with computation of properties based on statistical mechanics
  • Experience with theory or experiments in the fields of medicinal chemistry and computational chemistry, publications in related fields


Machine Learning Algorithm Scientist

Responsibility

  • Work with IT engineers and research scientists to build models to predicate the properties of drug-like modules and implement algorithms.
  • Develop and train machine learning models for the prediction based on the results from molecular force field and quantum chemistry
  • Develop and test software, algorithms and platforms

Qualifications

  • Master or PhD with a computation chemistry background
  • Experience with training machine learning models (classification, regression, clustering, recommendation system) and algorithm implementation
  • Excellent programming skills, familiar with at least one programming language (python, C, C++, FORTRAN, Java)
  • Good communication & interpersonal skills, team player and be self-motivated
  • Good English reading and writing skills

Desirable skills

  • Familiar with simulation based on molecular force field
  • Familiar with theory and protocols of quantum chemistry computation
  • Familiar with training tools such as tensorflow, Caffe, Scikit-learn, etc.
  • Experience with theory or experiments in the fields of medicinal chemistry and computational chemistry, publications in related fields


Algorithm Scientist

Responsibility
Work with research colleagues to develop algorithms of global optimization for crystal structure prediction and drug design.

Qualifications

  • Major in quantum chemistry, physical chemistry, condensed matter physics, applied maths, computational physics or related sciences
  • PhD or Master degrees or Bachelor with minimum three-year experience
  • Experience with scientific computing
  • Excellent programming skills, familiar with at least one programming language (python, C, C++, Fortran, Java)
  • Experience with global optimization algorithms
  • Good communication & interpersonal skills, team player and be self-motivated
  • Good English reading and writing skills


Algorithm Analysis Scientist

Responsibility

  • Work with research and IT colleagues to participate in the development algorithms for global optimization for crystal structure prediction and drug design
  • Test algorithms and software using our cloud computing platform
  • Write documents of cases

Qualifications

  • Major in quantum chemistry, physical chemistry, applied maths, computational materials and computer science or related sciences
  • PhD or Master degrees or Bachelor with minimum three-year experience Excellent programming skills, familiar with at least one programming language (python, C, C++, Fortran, Java,etc)
  • Experience with global optimization algorithms
  • Good communication skills
  • Good English reading and writing skills

Desired skills

  • Experience with global optimization algorithms
  • Experience with intermolecular interactions
  • Knowledge of basics of crystallography
  • Experience with theory or experiments in the fields of medicinal
  • chemistry and computational chemistry, publications in related fields
  • Knowledge of basics of quantum chemistry


Molecular Simulation Engineer

Responsibility

  • Work with research colleagues to develop and test force fields for drug-target interactions and crystals and run molecular dynamics simulations
  • Run molecular dynamics simulations
  • Parameterize force fields for drug molecules, summarize and analyze results
  • Develop and test new force fields

Qualifications

  • PhD or Master degrees in quantum chemistry, physical chemistry, medicinal chemistry, biochemistry or related sciences
  • Minimum one year experience with MD simulations, family with Linux and scripting

Desired skills

  • Experience with free energy perturbation and thermodynamic integration methods
  • Familiar with programming languages (python, C, C++, Fortran, Java, etc.)


Senior Crystallography Scientist

Responsibility

  • Work with IT and research colleagues to develop algorithms for predicting crystal structures of drug molecules
  • Work on algorithms and software for analyzing crystal structures
  • Work with IT colleagues to optimize algorithms and automatize our platform
  • Compute properties of crystals

Qualifications

  • Master or PhD in quantum chemistry, physical chemistry, medicinal chemistry, condensed matter physics, computational materials or related sciences
  • Crystallography background
  • Excellent research ability, ability to work independently

Desirable skills

  • Experience with intermolecular interactions
  • Knowledge of basics of crystallography
  • Experience with theory or experiments in the fields of medicinal chemistry and computational chemistry, publications in related fields
  • Knowledge of basics of quantum chemistry


Computational Chemistry Scientist

Responsibility

  • Work with IT and research colleagues to predict properties of drug molecules and develop patents of drugs
  • Work on cases with our computing platform
  • Write documents of cases
  • Test algorithms

Qualifications

  • Master or PhD in quantum chemistry, physical chemistry, medicinal chemistry, condensed matter physics, computational materials or related sciences
  • One year experience with quantum chemistry software suites
  • Familiar with Linux, ability to analyze data in Linux

Desirable skills

  • Experience with intermolecular interactions
  • Knowledge of basics of crystallography
  • Experience with theory or experiments in the fields of medicinal chemistry and computational chemistry, publications in related fields
  • Knowledge of basics of quantum chemistry




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