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Date: Mon Sep 25 17:30:53 2017
Subject: 17.09.25 Senior Research Scientist - Computational Chemistry, AstraZeneca, Sweden
Senior Research
Scientist -

Location: Gothenburg, Västra Götaland, Sweden
Job reference: R-014397
Posted date: Sep. 21, 2017

Placement: AstraZeneca R&D, Gothenburg, Sweden

Do you want join a world leading team in developing the next generation of respiratory medicines?

We now seek to recruit a Senior Research Scientist, Computational Chemistry, in the area of Respiratory, Inflammation & Autoimmunity (RIA)

AstraZeneca is committed to the development of the next generation innovative respiratory medicines. The Computational Chemistry team leads efforts to expand the use of state of the art in silico methods for modelling, ligand design, property predictions and data analysis supporting the RIA drug discovery projects with a focus on small to medium sized molecules. The team operates in a highly cross disciplinary environment in close collaboration with scientists from the Chemistry, Bioscience, DMPK and Pharmaceutical Science departments to advance the RIA project pipeline.

As a Computational Chemist you will have a profound impact on multiple projects across the RIA portfolio with a focus on early target identification (e.g. phenotypic screen) and lead generation including wide range of new modality chemistry such as stabilized peptides, conjugation chemistry, and oligonucleotides. You will have a key role in modelling, analysis of large datasets, drug design, and will be a significant contributor to project progression. The role holder will also provide discipline based scientific leadership and represent the department and AstraZeneca at interdisciplinary meetings internally as well as externally.

Main Duties and Responsibilities

  • Impact simultaneously multiple discovery projects (2-3) by efficiently and pro-actively applying a wide variety of computer-aided drug design approaches
  • The work will include helping project teams analyze, interpret, and visualize biological data, and communicate these results
  • With excellent knowledge of modern computational chemistry identify and drive areas of scientific improvements for computational chemistry
  • The candidate will be expected to plan, write and publish high quality scientific papers

Essential Requirements
We are seeking a drug hunter with a PhD (or equivalent experience) in computational chemistry, biophysics, or a related field, and preferable industry experience who would like to join our fast-pace multidisciplinary RIA computational chemistry team. The candidate is expected to have a high degree of independence and a proven record of excellence in a number of computer-aided drug design techniques to assist in target identification and advancement of discovery programs.

  • Solid knowledge of computational chemistry and medicinal chemistry concepts
  • Expertise in using computational chemistry software as well as knowledge in scientific computing, and programming skills (e.g. Python, Perl, C, C++, Java)
  • Preferable strong expertise in biophysics, structural modeling and methods to study protein dynamics
  • Very good written and verbal communication skills

Desirable Requirements

  • Preferable strong expertise in biophysics, structural modeling and methods to study protein dynamics

If you are interested, apply now at

For more information about the position please contact: Dr. Anders Hogner, Medicinal Chemistry, IMED RIA, at +46 31 7064586

Welcome with your application no later than October 16th, 2017.

AstraZeneca is a global, innovation-driven biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. In addition to being one of the world's leading pharmaceutical companies, AstraZeneca is proud to provide a unique workplace culture that inspires innovation and cross-boundary collaboration. The Respiratory, Inflammation & Autoimmunity (RIA) unit is one of AstraZenecas core therapy areas focused on the discovery and development of novel treatments for respiratory diseases.

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