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Up Directory CCL 17.08.15 Head of In Silico Medicinal Chemistry at The Institute of Cancer Research, London, UK
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Date: Wed Aug 16 05:54:42 2017
Subject: 17.08.15 Head of In Silico Medicinal Chemistry at The Institute of Cancer Research, London, UK
The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of Cancer
Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around
160 staff dedicated to the discovery and development of novel small molecule
therapeutics for the treatment of cancer. We are probably the largest academic cancer
drug discovery group in the world and, since 2010, 9 drugs discovered by CTU scientists,
either alone or in collaboration with a commercial partner, have been studied in our
ICR/Royal Marsden Drug Development Unit. Our drug abiraterone has been approved in
the US, Canada and Europe for late stage prostate cancer.

Our drug discovery is carried out in highly focused multi-disciplinary project teams,
analogous to those in a biotechnology company, with patient benefit as the primary
driver. Our team of 4 in silico medicinal chemists work alongside, chemists, structural
biologists, cancer biology, drug metabolism and computational biology experts focusing
on new molecular targets emerging from basic cancer biology research and clinical
studies. We publish our work extensively and have a large network of collaborations
with academia, biotechnology companies, and the pharmaceutical industry. Following a
recent international peer review exercise, our work was rated as Forefront/Outstanding.

A position in the CTU is now available to lead the In Silico Medicinal Chemistry team to
accelerate the progression of small molecule drug discovery projects by appropriate
development and application of in silico medicinal chemistry methods. The successful
candidate will be expected to both lead the team and be pro-actively and directly
involved in the application of computational methods to enhance our screening libraries
and to progress our portfolio of drug discovery projects from hit discovery to the
selection of preclinical development candidates.
Informal enquiries should be made to


Closing Date: Tuesday 5th September 2017
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