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Up Directory CCL 17.05.15 Postdoc, Multi-scale Simulation of Biocatalysts, University of Bristol, UK (Deadline: June 12th)
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Date: Mon May 15 06:07:01 2017
Subject: 17.05.15 Postdoc, Multi-scale Simulation of Biocatalysts, University of Bristol, UK (Deadline: June 12th)

Postdoctoral researcher in Multi-scale Simulation of Biocatalysts, University of Bristol, UK

A two-year Research Associate (PostDoc) position is available in the Van der Kamp group in Bristol. The main purpose of the role is to apply existing and new state-of-the-art methods in computational chemistry and enzymology to develop accurate and efficient protocols for simulation-led enzyme redesign on challenging enzyme systems, in collaboration with experimental partners. This will involve research in multiscale molecular simulation and modelling, enzyme mechanism and tool development, under supervision of Dr. Van der Kamp. Specific projects will be tailored to the expertise and interests of the appointed applicant. You will benefit from collaboration and interactions within the Centre for Computational Chemistry and the Bristol BioDesign Institute (which includes the BrisSynBio research centre), as well as ample computational resources (e.g. through the newly installed Phase 4 of the BlueCrystal HPC facility in Bristol, with over 800 TFLOPs the largest of its kind in a UK university).

Salary: 32,004 - 36,001 per year

Terms of employment: Full time. Open-ended contract with fixed term funding for 24 months in the first instance.

Start date: Flexible, but preferably before 15 Sept 2017.

Main job purpose
This position is linked to Dr. Van der Kamps David Phillips Fellowship, entitled Multi-scale enzyme modelling for SynBio: optimizing biocatalysts for selective synthesis of bioactive compounds. As part of this Fellowship, several projects are pursued, with an overarching theme of extending the applicability of combined quantum mechanical / molecular mechanical (QM/MM) modelling to model enzyme reactions and screening for activity and selectivity. Challenges related to chemical complexity as well as structural complexity (e.g. multi-domain enzymes) will be addressed. Depending on the experience and interests of the candidate, a suitable main project for the Research Associate can be defined, ideally combining existing skills of the candidate with additional skills that will be developed in the role. The position is to carry out research in biomolecular simulation and multiscale modelling relevant to biocatalysis, under the supervision of Dr Van der Kamp; to analyse and present results, including preparing them for publication, and to liaise with experimental collaborators involved in the research project, including demonstrating computational simulation methods.

Qualifications
Applicants should hold a PhD in (bio)chemistry or a related subject with a relevant specialisation in computational or theoretical chemistry, biochemistry or biophysics. Fluency in written and oral English, and proven experience of biomolecular simulation and specifically experience of protein molecular dynamics simulations or quantum mechanical calculations, or both. Programming experience and familiarity with shell scripting is an advantage.

For further information
Please contact Dr. Marc van der Kamp marc.vanderkamp:+:bristol.ac.uk

Application
Closing date for applications is midnight BST, Monday 12 June 2017.

If you see this advert after June 12th, but believe you are highly suitable for the role, please contact Marc.vanderKamp:+:bristol.ac.uk with a CV and a description of why you are interested to work in the Van der Kamp group.

The School of Biochemistry is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Bronze Award which recognises its good practice in relation to gender, including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance.

The University of Bristol is committed to creating and sustaining a fully inclusive culture. We welcome applicants from all backgrounds and communities.

How to Apply
Please apply via:

http://www.bristol.ac.uk/jobs/find/details.html?nPostingId=5945&nPostingTargetId=22696

If the above link doesn't work, please go to http://www.bristol.ac.uk/jobs/find and search for job number: ACAD102625

If you see this advert after June 12th, but believe you are highly suitable for the role, please contact Marc.vanderKamp:+:bristol.ac.uk with a CV and a description of why you are interested to work in the Van der Kamp group.

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Modified: Mon May 15 10:07:01 2017 GMT
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