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Date: Tue Apr 18 01:11:37 2017
Subject: 17.04.18 Computational Chemist at the Broad Institute Cambridge, MA USA
Req Number 3010

The Broad Institute is currently seeking to hire a motivated 
computational chemist to join the structural biology and modeling group
in the Center for the Development of Therapeutics (CDoT). The successful 
candidate will primarily support medicinal chemistry efforts to advance 
current therapeutic projects within the Center through structure-based 
and ligand-based modeling approaches. Work will be done in collaboration 
with scientists with extensive drug discovery experience in cell biology, 
biophysics, cheminformatics, computational chemistry, structural biology, 
analytical chemistry, protein science, and NMR.

Characteristic duties:
>Contribute to drug discovery efforts by applying computational chemistry
 approaches such as ligand docking, molecular dynamics simulations, 
 pharmacophore modeling, QSAR/ADMET models, and small library design.
>Generate, assess, and prioritize ligand designs using modeling tools 
 such as those found in Cresset, CCG, OpenEye, and Schrodinger packages.
>Analyze prospective protein targets for druggability and therapeutic 
 relevance using computational methods and available databases
>Communicate and collaborate effectively with medicinal chemists, 
 structural biologists and other members of cross-functional project 

*Experience in molecular dynamics simulations and free energy 
 perturbation calculations would be desirable
*Ph.D. in physical organic chemistry, computational chemistry, 
 computational biology, or related field is required
*Minimum 3 years of postdoctoral or industrial experience relevant to 
 drug discovery is preferred.
*Ability to work independently and collaboratively in a 
 multidisciplinary, team-oriented environment.
*Strong oral and written communication skills.
*State-of-the-art knowledge of standard and advanced computational 
 chemistry methods and software.
*Effective communication of data and structural designs using graphics 
 and interactive sessions.
*Demonstrated skills in the application of computer-assisted drug 
 design using modeling and computational software
*Analyzes literature and project data to generate hypotheses and novel 
*Able to handle multiple exploratory and drug discovery projects
*Working knowledge of medicinal chemistry and drug discovery
*Advanced knowledge of UNIX/Linux and queueing systems, and cloud 
 computing solutions to perform large calculations
*Programming experience in scripting languages including R and Python 
 and/or programming languages (Java, C, C++). Experience with web 
 application and database design desirable.
*Maintain and develop working knowledge of contemporary computational 
 chemistry methods and their use in ligand design and data analysis as 
 applied to drug design projects.

About CDoT
The purpose of the Center for the Development of Therapeutics (CDoT)
is to advance the Institute's diverse and growing number of exciting 
therapeutics projects. The mission of CDoT is to partner with 
researchers across the Broad community and external collaborators to: 
(1) drive forward Broad's therapeutics-focused projects 
    (in areas including oncology, cardiovascular disease 
    and diabetes, psychiatric disease, infectious disease, etc.); 
(2) provide a home for the Institute's cutting-edge therapeutics 
    expertise and methods; and 
(3) provide outreach to enable smaller-scale efforts in chemical biology 
    and screening at Broad. CDoT's current portfolio includes a 
    wide range of scientific projects being pursued with philanthropic 
    partners, biopharmaceutical companies and other collaborators; 
    the Broad is committed to continuing to build this portfolio over 
Please apply at:

The posting can also be found using Req Number 3010
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Modified: Tue Apr 18 05:11:38 2017 GMT
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