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Date: Thu Mar 16 06:03:41 2017
Subject: 17.03.14 PhD position in computational chemistry/biophysics (lipids+proteins), Czech Republic
Project: The aim of this project is to unravel the relationship between 
membrane-associated proteins and their preferred membranes. Despite 
a continuous exchange of material, organelles maintain a precise 
composition and morphology of membrane lipids, which is crucial for their 
function, the recruitment of specific peripheral proteins, and overall 
organization in space and time, without which serious diseases occur. 
Moreover, membrane curvature and lipid content can be specific to cancer 
cells, bacteria, and enveloped virus coatings, which could be utilized 
for selective targeting. The research will be strongly coupled 
to collaborations with excellent experimental teams and more closely 
discussed during the interview. The results will lay the foundations 
for the design of new protein motifs sensitive to membranes with a specific 
curvature and composition on enveloped viruses, organelles and cells. 
The student will master the tools of computer simulations and their 
analysis. Moreover, he/she will learn the advantages and disadvantages 
of various parameterizations.

Eligibility: Outstanding candidates with experience in computer simulations 
and with an MSc degree in biophysics, soft matter physics, physical 
chemistry, computational chemistry, stat. mechanics, or related fields. 
Experience with molecular dynamics (GROMACS, CHARMM, NAMD, AMBER, LAMMPS, 
etc.) or other simulation techniques (Monte Carlo, DPD, etc.) at the 
atomistic or coarse-grained level is an advantage. 

Computing Resources: Successful candidates will have access to local 
computing clusters with 1500 cores. Access to Metacentrum NGI  National 
Grid Infrastructure for computing (with ~10,000 cores) will be also 
available. Additional resources include the possibility of applying 
for IT4Inovations, where the group is active.

Competitive salary supported by grant projects, well above Czech average.
Applications must include a CV, list of publications, personal statement 
(description of research interests, past, and plans), and the names and 
emails of 2 people willing to provide a letter of recommendation. 
Applications with all of the material (preferably in a single pdf) should 
be sent to Robert Vacha (
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Modified: Thu Mar 16 10:03:41 2017 GMT
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