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Date: Tue Dec 6 11:12:50 2016
Subject: 16.12.06 Principal Computational Chemist / Molecular Modeller, Cancer Research UK, Manchester, UK.
As part of the on-going development of the CRUK Manchester Institute Drug 
Discovery Unit 
we are presently seeking a limited number of highly motivated, talented 
and experienced scientists with a track record of progressing small 
molecules toward clinical evaluation. Our aim is to understand the 
fundamental basis of cancer and apply that knowledge to developing new 
treatment strategies for cancer patients.  Our advanced research programmes
 span a spectrum of cancer research, from the molecular and cellular basis
 of cancer through to drug discovery, translational research and clinical 

The Institute has outstanding laboratory facilities and exceptional core 
services, including next generation sequencing, microarrays, confocal 
microscopy, bioinformatics, histology and mass-spectrometry.  We are 
situated in Manchester, England, a vibrant and dynamic city that is 
surrounded by beautiful countryside and has excellent transport links 
both nationally and internationally.

We are seeking an enthusiastic and proactive expert in Structure Guided 
Drug Design to help drive our programmes from early lead identification 
through to candidate selection.  An expert in the use of packages such as 
the Schrodinger Suite, MOE, Pipeline Pilot and Cresset to drive lead 
generation and lead optimisation activities, you will work closely with 
our synthetic and medicinal chemists. You will apply both our 
industry-standard tools and your own expertise, to help guide and focus 
chemistry strategy across our project portfolio, from hit identification 
to pre-clinical candidate selection and help identify future drug discovery

Alongside these project roles, you will have additional strategic 
responsibility for the future direction of our capabilities and 
collaborations in structure-guided drug design, structural biology and 
chemoinformatics. You will also play a key role in the specification, 
implementation and operation of our interactive drug design capability, 
currently in the planning phase.

The successful applicant should have a PhD in Chemistry or a related 
subject (or equivalent relevant experience).
To apply for this position please submit a CV and a completed CV cover 
sheet along with an equal opportunities form (both available at  and submit to: 
jobs/a\ quoting the reference number MI/16/84.
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