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Up Directory CCL 16.10.14 Computational Chemist, Silicon Therapeutics, Boston
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Date: Fri Oct 14 09:26:14 2016
Subject: 16.10.14 Computational Chemist, Silicon Therapeutics, Boston

Computational Chemist, Silicon Therapeutics, Boston

Silicon Therapeutics (STX) is a Boston based computational drug discovery company focused on using its proprietary INSITE technology to target high hanging fruit in drug discovery. It received finalized its series A financing and is seeking to hire a computational chemist to join in both developing INSITE and working on STX's internal pipeline. Competitive pay, equity, strong perks and fun working environment along with desire to do cutting edge science that straddles the boundary between theoretical and applied work are all good reasons to join us! Please email us at hr(!)silicontx.com with your resume and contact info. Please find job description below:

Responsibilities

  • Curate large library of commercially available chemicals with an emphasis on a large chemical space of drug-like compounds
  • Work on expanding compound library and improve accuracy of 3D structures using QM/MM MD simulations
  • Evaluate dynamics of in house protein targets and interface with structural biologists
  • Validate in house in silico drug discovery processes using the DUD and interface with drug discovery teams to support validation

Qualifications

  • Ph.D. in computational chemistry, medicinal chemistry, organic chemistry, physical chemistry, or biochemistry
  • Experience with a Unix/Linux environment, and scripting languages (e.g. Bash and Python)
  • Experience running MM and QM/MM molecular dynamics simulations and interpreting results
  • Experience in structure-based drug design and virtual high-throughput screening projects
  • Demonstrated track record of advancing drug discovery projects and publication record in top quality journals

Additional Qualifications

  • Track record of progressing compounds towards clinical candidates
  • Experience in medicinal chemistry including SAR analyses
  • Experience with C/C++ and parallel programming, especially for GPUs (e.g. MPI, OpenMP, OpenACC, CUDA C/C++/Fortran)


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