|CCL 16.10.05 Postdoc in Biophysical Molecular Simulation - Zuckerman Group - Portland, Oregon|
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Date: Thu Oct 6 15:10:39 2016
Subject: 16.10.05 Postdoc in Biophysical Molecular Simulation - Zuckerman Group - Portland, Oregon
Join the group of Prof. Daniel M. Zuckerman, which is working to push the limits of statistical-mechanics-based computations for biomolecules and systems biology. Our work employs statistical physics to understand the behavior of proteins, molecular machines, and their interactions. The group has just moved to the Center for Spatial Systems Biomedicine and the Dept of Biomedical Engineering at the Oregon Health & Science University in Portland. OHSU recently raised one billion dollars to fund the establishment of a new cancer center. The Zuckerman group is interested in binding and allostery, machine- like behavior of biomolecules, and drug design, as well as computational methods for studying these problems. We employ the atomistic models of molecular simulation and more coarse-grained descriptions including discrete-state kinetic models. We are attacking key technical problems in the field: simulation methods for equilibrium and non-equilibrium sampling of proteins and other biomolecules, free-energy/binding-affinity estimation, and flexible docking. The group has a long history of developing new algorithms, software, and databases, including multi-trajectory parallel methods and multi-scale methodology for combining coarse and detailed models. See http://tinyurl.com/DanielZuckerman A postdoc is being recruited to work on one or more projects. Likely projects include development and application of the weighted ensemble (WE) method for studying equilibrium and non-equilibrium behavior of biomolecules. Applications could include the study of protein (un)folding and (un)binding of small drug-like molecules to protein targets. Preliminary studies suggest WE could enable the massive speedup of protein folding and binding simulations. Data analysis will include the use of recently developed unbiased non-Markovian tools. Candidates must hold a PhD in Physics, Theoretical Chemistry, Chemical Engineering, Biophysics or related field. Candidates should have experience with programming (e.g., C, Python), scripting and software packages for molecular simulation (e.g., Amber, NAMD) and analysis (e.g., Matlab, Mathematica). Salary: $43,692.00 - 50,000.00 per year. Salary will depend on experience To begin the application process, please send your CV with a cover letter explaining your suitability for the position. Email these to zuckermd : ohsu.edu. About OHSU - Oregon Health & Science University Oregon Health & Science University is a renowned medical and research institution in Portland. Perhaps best known for recently raising one billion dollars for its new cancer center, OHSU has great strength in many areas, ranging from structural biology to super-resolution imaging and analysis. The city of Portland is famous for its great food, coffee, bike-friendliness, and proximity to all the natural beauty of the Pacific Northwest. Oregon Health & Science University values a diverse and culturally competent workforce. We are proud to be an equal opportunity, affirmative action organization. Individuals with diverse backgrounds and those who promote diversity and a culture of inclusion are encouraged to apply. Applicants with disabilities can request reasonable accommodation by contacting the Affirmative Action and Equal Opportunity Department at 503-494-5148.NOTE THAT E-MAIL ADDRESSES HAVE BEEN MODIFIED!!!
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