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Up Directory CCL 16.07.05 Senior Scientist, Computational Chemistry in Shanghai
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Date: Wed Jul 6 00:19:22 2016
Subject: 16.07.05 Senior Scientist, Computational Chemistry in Shanghai
We are looking for a dynamic individual to join our computational chemistry group. The successful candidate must have the drive and enthusiasm to handle multiple projects simultaneously. He/She must also represent BioDuro to multiple international clients and be able to interact across disciplines. 
The successful candidate will have a solid theoretical and practical knowledge of molecular modeling, cheminformatics, virtual screening, QSAR, and data mining. A keen interest in hypothesis-driven drug discovery, strong problem solving skills, and the ability to work in a team environment by engaging with cross-functional scientists are key elements of the role.
The ideal candidate will have a proven track record of applying computational chemistry techniques to advance small-molecule drug discovery programs and will be able to support various database and software systems to collect, disseminate, and analyze pre-clinical discovery data to our internal and external scientists.
The position will be based at BioDuros Shanghai facilities.


	Work closely with clients, such as major international pharmaceutical and biotech companies on their drug discovery programs
	Responsible for providing computational chemistry support to structure-, ligand- and fragment-based drug discovery projects as well as virtual screening efforts
	Utilize software for in silico prediction of ADME, biology, and safety properties
	Develop QSAR model for data analysis
	Work collaboratively with chemists and project teams to design compounds with improved potency, selectivity, functional activity and/or ADME properties
	Support various database and software systems to collect, disseminate, and analyze all pre-clinical small molecule discovery data to our internal and external scientists


	A M.S. (or equivalent) in Computational Chemistry, Organic Chemistry or a related discipline
	Experience in scripting or programming
	Hands-on experience in one or more of the following areas: structure-based drug design including docking, homology modeling, molecular dynamics simulation, free energy calculation; ligand-based drug design including pharmacophore modeling, QSAR, 3D-QSAR, pharmacophore- or shape-based database searching, combinatorial and fragment library design, focused library construction, R-group decomposition, pairwise matching, cliff analysis
	Familiarity with state-of-the-art modeling and cheminformatics tools such as Maestro, MOE, Gold, JChem, Vortex, Spotfire, Knime, etc.
	Strong problem solving skills and the ability to work in a fast-paced environment
	Fluency in written and spoken English

Preferred Requirements:

	Expertise with a wide array of computational methods
	Pharma or biotech experience with a focus on computational chemistry and strong understanding of drug design principles 
	Solid understanding of medicinal chemistry concepts and demonstrated success in addressing medicinal chemistry design challenges
	Familiarity with common programming languages such as Perl, Java and C++, as well as functional familiarity with web technologies
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