Vitae Pharmaceuticals is an emerging pharmaceutical company 
dedicated to being a leader in rapidly discovering, developing 
and commercializing innovative, high value small molecule 
medicines, focusing on known biologic targets with significant 
unmet medical need. Vitae's lead programs are rapidly advancing 
in therapeutic areas that include cardiovascular disease, diabetes 
and metabolic disease and Alzheimer's disease.

Vitae's approach to value generation begins with a unique 
discovery engine. Vitae was founded with the goal to create a
paradigm breakthrough in the field of structure-based drug design. 
CONTOUR, the result, is a computational structure based design 
platform that delivers superior drug design precision, novelty and 
speed, yielding high value drug candidates. 

A successful candidate will be responsible for designing novel 
molecules using proprietary structure based design tools, and 
be integral part of the medicinal chemistry efforts at Vitae. In 
addition a thorough knowledge of and expertise in the use of 
commercial software applications for structure based design is 
essential. An excellent understanding of physical chemistry, 
specifically thermodynamic principles, with experience in 
applying it to structure-based drug design is essential. A good 
understanding of organic chemistry required for designing 
synthetically viable compounds is highly desirable.  The designed 
compounds with a good physical chemistry rationale and backed 
by synthetic feasibility are expected to be presented on a weekly
basis to the project team. 

A Ph.D. in one of the following fields is required: physical organic, 
computational chemistry, physical chemistry or its equivalent.

Expertise in computational structure based design 
methodologies including de novo design, docking and scoring, 
free energy perturbation, quantum mechanical methods, and SAR 
analysis is highly desired.  5+ years of experience in working closely
with medicinal chemists is essential. Excellent written and 
oral communication skills are highly desirable.

Please send CV to careers!^!vitaerx.com