Scientist/Senior Scientist - Computational Chemistry  Plexxikon Inc

As a leader in structure-based drug discovery, Plexxikon is seeking a 
highly motivated and experienced computational chemist to join our 
Informatics Department. Working in a multidisciplinary team environment, 
the successful candidate will use computational modeling and other 
technologies to aid in the discovery and optimization of novel drug 
candidates for targets in specific therapeutic programs.  In this 
position, you will play a critical role in providing input for inhibitor 
design and lead optimization, along with a team of experienced scientists 
in structural biology, assay biology, computational chemistry, and 
medicinal chemistry. Plexxikon is a development-stage company with a 
strong commitment to getting the best compounds into our growing pipeline. 
This is a tremendous opportunity for a computational chemist to have a 
direct impact on the discovery of future medicines. 

The ideal candidate will have extensive experience with iterative 
structure-guided lead generation with record of success. In-depth 
knowledge of the principles of medicinal chemistry and pharmacology is 
essential, as is broad experience in late stage lead optimization of 
ADME/Tox properties. Preferred Candidates are also expected to have 
experience in some of the following areas: combinatorial library design, 
3D pharmacophore/docking approaches, molecular dynamics simulations, free 
energy methods, QM/electronic structure calculation, and small molecule 
conformational analysis. Programming experience in Perl, Python, Java, 
and/or C/C++ is required. 

This position requires a PhD in Chemistry, Pharmacology, or a closely 
related field with 3+ years experience in the research environment of a 
biotech or pharmaceutical company. A track record of accomplishments 
demonstrating technical proficiency, independent thought, scientific 
creativity, and collaboration with others is required, as is excellent 
communication skill, both written and oral.  Expert knowledge of 
scientific principles and concepts in the field is expected, as is the 
ability to serve as a resource for colleagues. 

If you are interested in applying for this position, please submit your 
resume or CV, cover letter, and include the job title in your application. 
All submissions will be evaluated and interviews will be conducted for 
those applicants who most strongly fit our needs. 

For details on Plexxikon, please visit http://www.plexxikon.com 

Mail: Human Resources
Plexxikon Inc.
91 Bolivar Drive
Berkeley, California 94710
Fax: 510.647.4090
Email: careers:plexxikon.com

E-mailed resumes should be attached as Text or Word documents. The 
subject should include the job title.

Plexxikon is an equal opportunity employer.