From owner-chemistry@ccl.net Sat Feb 24 15:18:00 2018 From: "Rajarshi Guha rajarshi.guha.:.gmail.com" To: CCL Subject: CCL: Call for Papers (ACS Fall Meeting 2018) Move Away from the Lamp post & Find Druggable Targets Message-Id: <-53206-180223160131-14178-6kPl6nhWi+sq5D7ucZPmUA[A]server.ccl.net> X-Original-From: Rajarshi Guha Content-Type: multipart/alternative; boundary="001a11471bfc4b0d460565e776cc" Date: Fri, 23 Feb 2018 16:01:19 -0500 MIME-Version: 1.0 Sent to CCL by: Rajarshi Guha [rajarshi.guha/a\gmail.com] --001a11471bfc4b0d460565e776cc Content-Type: text/plain; charset="UTF-8" Content-Transfer-Encoding: quoted-printable 256th ACS National Meeting Boston August 13-23, 2018 CINF Division Dear colleagues, we are organizing a symposium focusing on methodologies and case studies that have explored under- or unstudied targets, with the goal of elucidating their function or role in the context of human disease. Several reports have highlighted the focus on current biomedical research on a relatively small set of protein targets. For example, Edwards et al (Nature, 2011) reported that 75% of research is focused on studying only 10% of the known mammalian proteins. Clearly, there may be many unexplored opportunities among the set of under- and unstudied targets, the so called =E2=80=9Cdark targets=E2=80=9D. Our o= wn report (Oprea et al, Nature Rev Drug Discov 2018 https://www.nature.com/articles/nrd.2018.14) suggests that as many as 38% of human proteins are significantly understudied, and that over 9000 human proteins are currently not associated with NIH funding. At this critical juncture in human health research, we believe it is timely to discuss approaches to study the "dark genome". We invite submissions that address all aspects of illuminating dark targets, with a particular focus on computational approaches that involve novel experimental methods. Topics of interest include, but are not limited to: * Target prioritization methods * Integrative approaches that combine data types, using well studied targets to shed light on unstudied targets * Case studies that have elucidated function or disease relevance for unstudied targets * Novel characterization of targets that go beyond traditional structure based approaches * Target-centric databases that highlight dark targets The deadline for abstract submissions is March 20, 2018. All abstracts should be submitted via MAPS at https://acsnm256.abstractcentral.com/. If you have any questions feel free to contact Tudor or myself Rajarshi Guha NCATS, NIH guhar::nih.gov Tudor Oprea University of New Mexico TOprea::salud.unm.edu --=20 Rajarshi Guha | http://blog.rguha.net National Center for Advancing Translational Science --001a11471bfc4b0d460565e776cc Content-Type: text/html; charset="UTF-8" Content-Transfer-Encoding: quoted-printable
256th ACS National Meeting=C2=A0
Boston Aug= ust 13-23, 2018
CINF Division

Dear colle= agues, we are organizing a symposium focusing on methodologies and case stu= dies that have explored under- or unstudied targets, with the goal of eluci= dating their function or role in the context of human disease. Several repo= rts have highlighted the focus on current biomedical research on a relative= ly small set of protein targets. For example, Edwards et al (Nature, 2011) = reported that 75% of research is focused on studying only 10% of the known = mammalian proteins.=C2=A0

Clearly, there may be ma= ny unexplored opportunities among the set of under- and unstudied targets, = the so called =E2=80=9Cdark targets=E2=80=9D.=C2=A0 Our own report (Oprea e= t al, Nature Rev Drug Discov 2018 https://www.nature.com/articles/nrd.2018.14) suggests th= at as many as 38% of human proteins are significantly understudied, and tha= t over 9000 human proteins are currently not associated with NIH funding.

At this critical juncture in human health research,= we believe it is timely to discuss approaches to study the "dark geno= me". We invite submissions that address all aspects of illuminating da= rk targets, with a particular focus on computational approaches that involv= e novel experimental methods. Topics of interest include, but are not limit= ed to:

* Target prioritization methods
*= Integrative approaches that combine data types, using well studied targets= to shed light on unstudied targets
* Case studies that have eluc= idated function or disease relevance for unstudied targets
* Nove= l characterization of targets that go beyond traditional structure based ap= proaches
* Target-centric databases that highlight dark targets

The deadline for abstract submissions is March 20, = 2018. All abstracts should be submitted via MAPS at https://acsnm256.abstractcentral.com/. If yo= u have any questions feel free to contact=C2=A0 Tudor or myself
<= br>
Rajarshi Guha
NCATS, NIH

Tudor Oprea
University of New Mexico

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Rajarshi Guha | http://blog.rguha.net
National Center = for Advancing Translational Science
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